基于脑白质疏松的血管源性轻度认知障碍 DTI 研究  

The DTI in the evolution of vascular cognitive impairment mechanism based leukoaraiosis

作　　者：庞冉[1] 赵晶[1] 张允岭[1] 金香兰[1] 刘明[1] 

机构地区：[1]北京中医药大学东方医院放射科,北京100078

出　　处：《实用放射学杂志》2014年第7期1071-1074,共4页Journal of Practical Radiology

基　　金：科技部中医药行业科研专项（200807011,201007002）;北京市社区中医药服务科技示范项目（JJT2010-03）.

摘　　要：目的：探讨基于脑白质疏松的血管源性轻度认知障碍（VaMCI）患者脑白质完整性的变化特点。方法对有脑白质疏松者行神经心理学评估,筛选出48例 VaMCI 患者和18例无认知障碍患者（NC 组）,行 DTI 扫描测定以下两侧对称部位兴趣区的FA 值和 ADC 值：嗅内侧回白质、海马穹窿、胼胝体前部及后部、额叶下回白质、颞叶上回白质及枕叶角回白质。统计分析组间 DTI数据的差异及与神经心理评分的相关性。结果与 NC 组比较,VaMCI 组左侧额下回、左侧胼胝体前部、左侧海马穹窿及右侧角回ADC 值明显增高（P 〈0.05）,左侧海马区 ADC 值与 MoCA 评分呈明显负相关（r=-0.34,P =0.02）。FA 值在组间无明显统计学差异（P 〉0.05）。结论 VaMCI 患者多个认知相关脑区的 ADC 值减低。Objective To explore the integrity of white matter changes in patients with vascular mild cognitive impairment （VaMCI）based Leukoaraiosis.Methods The patients which appeared white matter hyperintensities in subcortical were performed psychological testing,then 48 VaMCI patients and 18 without cognitive impairment volunteers（NC）were choosed and performed DTI scanning,to determine the white matter’s values of FA and ADC in the following bilaterally symmetrical regions of interest（ROI）：entorhinal cortex lobe,hippocampal vault,anterior of corpus callosum,posterior of corpus callosum,inferior frontal lobe,superior temporal lobe and angular gyrus of occipital lobe. Then the differences of the data of DTI between two groups and the relevance between neuropsychological score and DTI’s data were analysed.Results ADC values were significantly higher of VaMCI group in the left inferior frontal lobe,left anterior of corpus callo-sum,left hippocampus vault and right angular gyrus compared with NC group（P 〈0.05）,and in the left hippocampus ADC values and MoCA scores was negatively correlated（r=-0.34,P =0.02）.There was no significant difference of FA values between groups. Conclusion The ADC values in many cognitive related areas was reduced in VaMCI patients.

关 键 词：血管源性认知障碍 脑白质疏松 扩散张量成像 

分 类 号：R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]