早期双相情感障碍 I 型脑灰质基于体素形态学初步研究  

Preliminary voxel-based morphometry analysis of grey matter abnormalities in early stage of bipolar disorder I

作　　者：邹文锦[1] 曹莉萍[2] 崔立谦[3] 李烜[2] 黄癸卯[1] 孙翀鹏[4] 老帼慧[2] 陈健华[2] 欧玉芬 邓文皓[2] 李新春[4] 

机构地区：[1]广州医科大学附属脑科医院放射科,广东广州510370 [2]广州医科大学附属脑科医院精神科,广东广州510370 [3]广州医科大学附属第一医院心理科 [4]广州医科大学附属第一医院放射科

出　　处：《实用放射学杂志》2014年第7期1075-1079,共5页Journal of Practical Radiology

基　　金：广东省自然科学基金博士启动项目（S2011040003729）广东省医学科学技术研究基金（A2013261）.

摘　　要：目的：探讨早期双相情感障碍（BD）Ⅰ型患者脑灰质体积变化及相应异常的脑区,为早期诊断 BD 提供客观依据。方法纳入17例病程〈2年的 BD I 型患者及17例正常对照,运用基于体素形态学（VBM）方法分析组间全脑灰质体积差异,统计阈值取〉100个体素集合,P 〈0.001（未校正）。结果与对照组比较,BD 病例组左侧前扣带回背后部、左侧岛叶、右侧前扣带回膝前部、左侧颞上回、双侧海马-海马旁回-杏仁体、左侧小脑后叶灰质体积明显减小（P 〈0.001）。结论早期 BD 患者脑灰质表现为体积减小,主要位于双侧边缘系统、左侧颞上回及小脑皮层,可能是 BD 早期结构病理表现。Objective To estimate brain grey matter volume changes and location of abnormal brain regions cerebrum in early stage of bipolar disorder I （BD）,in order to provided objective basis for diagnosing early stages BD.Methods 1 7 cases of BD with duration less than 2 years and 1 7 normal controls were recruited in this study.The volumetric difference of grey matter between two groups were analyzed by using voxel-based morphometry（VBM）software.Statistical threshold was voxel〉 100,P 〈0.001 （uncor-rected）.Results Compared to the normal controls,the grey matter volume of BD patients decreased in the left dorcial anterior cingu-late cortex（ACC）,left insular,right sub-genu ACC,left superior temporal cortex,bilateral hippocampus-parahippocampus-amydala and left posterior lobe of cerebellum（P 〈0.001）.Conclusion The grey matter volume of early stage BD patients is decreased,main-ly locating in the bilateral limbic system,the superior temporal gyrus and the cerebellar cortex,which probably is the morphological appearance of pathomechanism in early stages of BD.

关 键 词：双相情感障碍 基于体素形态学研究 脑灰质 体积 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R322.81[医药卫生—临床医学]