颅内动脉瘤夹闭术前后血流动力学变化的CTP 对比研究  

A comparative study of using the CTP imaging to evaluation the hemodynamic changes before and after clipping of intracranial aneurysm

作　　者：张乾营[1] 何明颖[1] 李嘉家[1] 黄莹[1] 何桂凤[1] 刘旭红[1] 

机构地区：[1]解放军第180医院医学影像科,福建泉州362000

出　　处：《实用放射学杂志》2014年第7期1083-1087,共5页Journal of Practical Radiology

摘　　要：目的：利用 CT 灌注成像来探讨颅内动脉瘤夹闭术前后脑微循环变化。方法回顾分析70例经 CTA 确诊颅内动脉瘤患者的 CTP 图像,按照手术前后是否出现血管痉挛（CVS）分为4组。A 组：术前 CVS、术后 CVS（4例）；B 组：术前 CVS、术后nCVS（13例）；C 组：术前 nCVS、术后 CVS（20例）；D 组：术前 nCVS、术后 nCVS（33例）。测量4组动脉瘤夹闭术前与术后 CBV、CBF、MTT 值,并进行统计学分析。结果（1）术前及术后 CBVA,B,C,D 、CBFA,B,D 、MTTA,B 值比较,P 值均〈0.05,差异有统计学意义。术前及术后 CBFC 、MTTC,D 值比较,P 值均〉0.05,差异均无统计学意义。（2）△CBVBC,BD 、△CBFAB,BC,BD 及△MTTAB,BD ,P 值均〈0.05,差异有统计学意义。△CBVAB,AC,AD,CD 、△CBFAC,AD,CD 、MTTAC,AD,BC,CD ,P 值均〉0.05,差异无统计学意义。结论 CTP能够早期、准确地预测颅内动脉瘤夹闭术前与术后的微循环改变。Objective To explore the change of cerebral microcirculation before and after clipping of intracranial aneurysm using CT perfusion （CTP）imaging.Methods CTP images of 70 patients diagnosed intracranial aneurysm by CTA were retrospectively an-alysed.They were divided into four groups according to have or not intracranial arterial spasm：A group：Preoperative CVS,postop-erative CVS （4 cases）,B group：Preoperative CVS,postoperative nCVS （13 cases）,C group：Preoperative nCVS,postoperative CVS （20 cases）,D group：Preoperative nCVS,postoperative nCVS （33 cases）.CBV/CBF/MTT were measured in four groups be-fore and after surgery,and analyzed statistically.Results （1）The postoperative CBV/CBF/MTT was compared with the preopera-tive data.There were statistically significant in CBVA/B/C/D/CBFA/B/D/MTTA/B during the surgery （P 〈0.05 ）.There were no statistically significant in the CBFC and MTTC/D during the surgery （P 〉0.05）.（2）There were statistically significant in the△CBVBC/BD/△CBFAB/BC/BD/△MTTAB/BD （P 〈 0.05 ）.△CBVAB/AC/AD/CD/△CBFAC/AD/CD/△MTTAC/AD/BC/CD were no statistically significant （P ＆gt;0.05）.Conclusion CTP can early and accurately predict the change of cerebral microcircu-lation after surgery.

关 键 词：颅内动脉瘤 动脉瘤夹闭术 脑血管痉挛 微循环 

分 类 号：R739.41[医药卫生—肿瘤] R743[医药卫生—临床医学]