不同分子亚型乳腺癌X线征象及病理特征分析  

Mammographic features and pathological characteristics among different molecular subtypes of breast cancer

作　　者：梁晓燕[1] 康晓丽[1] 秦静 王涛[1] 黄颖[1] 樊民义[1] 刘辉[1] 

机构地区：[1]陕西省人民医院放射科,陕西西安710068 [2]眼科,陕西西安710068

出　　处：《实用放射学杂志》2014年第7期1133-1136,共4页Journal of Practical Radiology

基　　金：陕西省科学技术研究发展计划项目（2013K12-03-19）。

摘　　要：目的：探讨不同分子亚型乳腺癌的 X 线征象及病理特征。方法收集经手术病理证实为乳腺癌的210例患者资料,对其进行分子分型,对比分析不同分子亚型乳腺癌的 X 线征象、病理特征。结果210例乳腺癌中,Luminal 型147例,HER-2（＋）型30例,三阴性型33例。3组病例淋巴结转移、组织分级差异有统计学意义（P 均〈0.05）。3组病例在是否表现为肿块、肿块边缘及有无钙化差异有统计学意义（P 〈0.05）；肿块大小、形态差异无统计学意义。Luminal 型多表现为典型毛刺肿块征象；HER-2（＋）型 X 线表现多样,钙化多见；三阴性型多表现为肿块,边缘清晰,少有钙化。结论不同分子分型的 X 线征象各有一定特点,病理特征存在差异。Objective To analyze the mammographic features and pathological characteristics among different molecular subtypes of breast cancer.Methods The results of 210 cases breast cancer identified by postoperative pathology were collected and classified to three groups;Luminal,HER-2（＋）and TNBC（triple negative breast cancer）by molecular subtypes.Three groups＆#39;mammograph-ic features and pathological characteristics were compared.Results 210 cases included 147 Luminal cases,30 HER-2 （＋）cases and 33 TNBC cases.There were statistically significant difference between tumor grading and lymph node metastasis （P 〈0.05）.Three groups had statistically significant difference among mass number,mass margin and calcification incidence（P 〈0.05）,and had no sta-tistically significant difference between mass size and shape（P 〉0.05）.The mammographic features of Luminal molecules subtypes showed more mass with burr,HER-2（＋）molecules subtypes showed no fixed features but more calcification incidence than other groups,TNBC molecules subtypes showed merely mass with clear margin and less calcification.Conclusion The mammographic fea-tures and pathological characteristics of different molecular subtypes of breast cancer are significant differences.

关 键 词：乳腺癌 分子分型 乳腺X线摄影 

分 类 号：R737.9[医药卫生—肿瘤] R814.41[医药卫生—临床医学]