黛力新对伴有躯体疼痛的抑郁症患者痛觉诱发电位P250影响的对照研究  

Effect of Deanxit on Electrical Pain-related Evoked Potentials P250 in Depression Patients with Pain Symptom of Body

作　　者：冯新梅 

机构地区：[1]江苏省仪征市第二人民医院精神科,中国211400

出　　处：《中国健康心理学杂志》2014年第9期1310-1312,共3页China Journal of Health Psychology

摘　　要：目的：探讨黛力新对伴有躯体疼痛的抑郁症患者痛觉诱发电位P250的影响。方法接受米氮平治疗（30～45mg/d）的、伴有躯体疼痛症状的抑郁症患者，随机分组后分别加用黛力新（黛力新组，n＝25）和不加用黛力新（对照组，n＝25）治疗，于治疗前、治疗后4周测定电刺激痛觉诱发电位P250的潜伏期、波幅，并进行对照研究。结果①两组治疗后P250波幅均较治疗前显著下降，差异有统计学意义（t＝4．139，2．250；P＝0．000，0．034）；P250潜伏期则均与治疗前无显著差异（P＞0．05）；②黛力新组治疗后P250波幅的下降率显著高于对照组，差异有统计学意义（t＝2．328，P＝0．024）。结论黛力新可下调伴有躯体疼痛的抑郁症患者痛觉诱发电位P250的波幅，提示黛力新对其痛觉敏感性有一定的改善作用。Objective To investigate the effect of deanxit on electrical pain -related evoked potentials P 250 in depressed patients with pain symptom of body .Methods Inpatients with somatic pain receiving mirtazapin （30-45mg/d） treatment were randomly divided into two groups,with deanxit（deanxitgroup,n=25） or without deanxit（control group,n=25）, measured by pain-related evoked potentials before and after 4 weeks treatment .Results The amplitude of P250 was significantly reduced after treatment in deanxit group （ t=4.139,P=0.000）and control group （t=2.250,P=0.034）.The P250 latency was not significantly changed in both two groups （both P〉0.05）.The averaged delta ratio of P250 amplitudes was significantly higher in deanxit group compared with control group （t=2.328, P=0.024）.Conclusion Deanxit should have effects on down -regulating P250 amplitude in depression with pain symptom of body , which suggests the improvement of pain sensitivity .

关 键 词：抑郁症 疼痛 诱发电位 黛力新 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R749.053[医药卫生—临床医学]