生长激素释放肽在功能性消化不良中的研究进展  

Research progress of ghrelin on the functional dyspepsia

作　　者：吕林[1] 黄穗平[2] 唐旭东[3] 

机构地区：[1]广州中医药大学,广州医学博士研究生510405 [2]广东省中医院消化科,广州510105 [3]中国中医科学院西苑医院消化科,北京100091

出　　处：《医学研究生学报》2014年第7期755-759,共5页Journal of Medical Postgraduates

基　　金：国家重点基础研究发展计划973项目(2013CB531703)

摘　　要：功能性消化不良(functional dyspepsia,FD)是一种常见的功能性胃肠道疾病,造成FD的病因目前尚未完全阐明。生长激素释放肽(Ghrelin)是一种主要由胃的内分泌细胞(X/A样细胞)分泌的脑肠肽。受体在体内广泛分布,具有调节生长激素分泌、摄食和能量平衡,影响神经内分泌及胃肠功能等多种生物学作用。越来越多的研究表明Ghrelin在FD中对于提高摄食量、产生饥饿感及促进胃排空方面有积极作用。目前,Ghrelin已成为研究FD的新热点。Functional dyspepsia is a common functional gastrointestinal disease , however , the cause of functional dyspepsia has not been fully elucidated .Ghrelin is braingut petide , secreted by major endocrine cells of the stomach （ x/A like cells ） .Its recep-tor is widely distributed in the body .It has many kinds of biological effects , such as regulating growth hormone secretion , feeding and energy balance , affecting neuroendocrine and gastrointestinal function and so on .A growing number of studies have shown that Ghrelin in FD has a positive role in increasing the improvement of food intake and generating hunger , promoting gastric emptying .Ghrelin is a new hot spot in the research of FD .

关 键 词：功能性消化不良 生长激素释放肽 胃肠激素 消化系统 治疗药物 

分 类 号：R57[医药卫生—消化系统]