S100A7的生物学特性及其与疾病的关系  

S100A7:Biological properties and implications in diseases

作　　者：刘烨[1] 孙文艳[1] 龙建纲[1] 刘健康[1] 

机构地区：[1]西安交通大学生命学院生物信息学中心线粒体生物医学研究所

出　　处：《医学研究生学报》2014年第7期767-771,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金(31370844)

摘　　要：S100A7是一种小分子钙结合蛋白,广泛参与到上皮细胞的分化、皮肤化学防御体系的构建、氧化应激和炎症反应的发生等生命过程,其分泌可由物理、化学和生物等多方面因素诱导。S100A7具有多种结合配体,并通过特定的信号通路与活性氧类密切相关。作为皮肤的一种重要抗菌肽,S100A7能帮助人体表皮抵御常见致病微生物的侵袭。S100A7也在多种皮肤病中表达上调,是反映皮肤细胞分化程度和炎症状态的关键指标。另外,脑组织神经元中S100A7的高表达可阻止阿尔兹海默症患者脑中淀粉样蛋白的沉积。S100A7在某些肿瘤组织中也呈现高表达,与癌症的发生和恶化密切相关。文中介绍S100A7的生物学特性及功能,总结S100A7在多种疾病中的表达特征和作用机制,为寻找S100A7相关疾病的分子标记物和作用靶点提供新思路。S100 A7 is a small calcium-binding protein that has an important role to play in the differentiation of human kerati -nocytes.It also helps build the chemical defense system of the skin and responds to oxidative stress and inflammation .The expression of S100 A7 can be induced by physical , chemical and biological stimulations .S100 A7 has many ligands and is related to the reactive oxygen species （ROS） via specific signaling pathways.As an important antimicrobial peptide, S100A7 helps the skin fight against main pathogens .S100 A7 is also a key indicator for the state of inflammation and cell differentiation;and its up-regulation has been cor-roborated in various skin diseases .In the brain of patients with Alzheimer′s disease, the up-regulation of S100A7 in primary cortico-hippocampal neurons can inhibit the generation of β-amyloid peptides .Moreover , S100 A7 is also up-regulated in different types of cancer and closely related to tumor malignancy and progression .In this review, we introduce biological properties of S 100A7 and high-light its expression characteristic in related diseases .This should have implication for the discovery of potential biomarkers and targets for the treatment of S100A7-related diseases.

关 键 词：S100A7 抗菌肽 结合配体 活性氧类 疾病 

分 类 号：Q514[生物学—生物化学]