鼻咽癌高发区人群初筛后1年随访结果分析  

Analysis of follow-up results one year after initial screening in high-risk area of nasopharyngeal carcinoma

作　　者：王盼盼[1,2] 季明芳[1] 吴标华[1] 

机构地区：[1]中山大学人民医院肿瘤研究所,广东省中山市528403 [2]中山大学肿瘤防治中心,华南肿瘤学国家重点实验室

出　　处：《中国肿瘤临床》2014年第14期900-903,共4页Chinese Journal of Clinical Oncology

基　　金：国家"十一五"科技支撑计划项目(编号:2006BAI02A11);中央补助地方公共卫生专项资金癌症早诊早治项目资助~~

摘　　要：目的:观察高发区初筛1年后鼻咽癌一级亲属、一般人群血清EB病毒抗体的动态变化及鼻咽癌检出情况。方法:收集参加2009年8月至2010年7月广东省中山市小榄镇鼻咽癌初筛和2011年8月随访的人群EB病毒血清学资料与鼻咽癌检出情况,比较鼻咽癌一级亲属和一般人群中EB病毒抗体变化及鼻咽癌检出情况。结果:亲属组NA1/IgA转阴率高于对照组(χ2=20.28,P<0.001),且男、女性亲属组分别高于男、女性对照组(χ2=22.59,P<0.001;χ2=4.03,P<0.05);亲属组NA1/IgA转阳率低于对照组(χ2=7.79,P=0.005),男性亲属组高于男性对照组(χ2=9.46,P=0.002),而女性亲属组与女性对照组比较差异无统计学意义(χ2=0.74,P>0.05)。亲属组VCA/IgA转阴率高于对照组(χ2=1.90,P=0.001),男性亲属组高于男性对照组(χ2=7.50,P=0.005),而女性亲属组与女性对照组比较差异无统计学意义(χ2未见表达,P>0.05)。亲属组VCA/IgA转阳率高于对照组,但差异无统计学意义(χ2=0.10,P>0.05)。亲属组未检出新发鼻咽癌,对照组检出10例,对照组鼻咽癌检出率显著高于亲属组,但差异无统计学意义(χ2=1.05,P>0.05)。结论:EB病毒的变化与遗传因素可能不存在密切联系;初筛后鼻咽癌一级亲属鼻咽癌检出并不高于一般人群,可能无需采取选择性随访原则。Objective：To observe the differences in the dynamic change of the EB virus antibody between general population and first-degree relatives （FDR） of nasopharyngeal carcinoma patients during follow-up study one year after initial screening and discuss the difference among the nasopharyngeal carcinoma detections. Methods： Serologic data of all subjects that participated in the follow-up study were collected. Changes in EB virus antibodies were investigated and correlation of these changes with gender and age level was analyzed. Differences in the nasopharyngeal cancer detection rate of different populations were also compared. Results：NA1/IgA negative conversion rate was higher in the family group than in the control group （χ^2=20.28, P〈0.001）. This rate was also higher in both male and female family groups than in the male and female control groups （χ^2=22.59, P〈0.001;χ^2=4.03, P〈0.05, respectively）. NA1/IgA positive conversion rate was lower in the family group than in the control group （χ^2=7.79, P〈0.05）. Likewise, this rate was lower in both male and female family groups than in the male and female control groups （χ2=9.46, P〈0.05;χ^2=0.74, P=0.39, respective-ly）. VCA/IgA negative conversion rate was higher in the family group than in the control group （χ^2=1.90, P〈0.001）. This rate was also higher in the male and female family groups than in the male and female control groups （χ^2=7.50, P〈0.05; χ^2=no expression, P=0.108, determined by Fish exact test, respectively）. VCA/IgA positive conversion rate was higher in the family group than in the control group （χ^2=0.10, P=0.70）. This rate was again higher in both male and female family groups than in the male and female control groups （χ^2=0.02, P=0.90,χ^2=0.51, P=0.48, respectively）. Ten cases from the control group manifested nasopharyngeal carcinoma;the same disease was not observed in the family group. Nasopharyngeal carcinoma detection rate was significantly higher in the control group than in t

关 键 词：鼻咽癌 EB病毒 抗体 随访 一级亲属 

分 类 号：R739.63[医药卫生—肿瘤]