晚期非小细胞肺癌患者化疗时应用护肝药物的临床意义分析  

Clinical Analysis of Application of Protecting Liver Drugs in Advanced Non-small Cell Lung Cancer Patients who Receiving Chemotherapy

作　　者：张磊[1] 王江峰[2] 毛伟敏[2] 

机构地区：[1]浙江省绍兴市第六人民医院,312000 [2]浙江省肿瘤医院,杭州310022

出　　处：《医学研究杂志》2014年第7期87-89,共3页Journal of Medical Research

基　　金：浙江省中医药防治重大疾病攻关计划基金资助项目(2011ZGG001)

摘　　要：目的研究预防性使用护肝药物在晚期非小细胞肺癌患者化疗过程中,是否使肝功能损伤发生率降低。方法回顾性分析在浙江省肿瘤医院就诊138例晚期非小细胞肺癌患者,化疗前是否接受预防性使用护肝药物,用卡方检验肝功能受损是否存在差异,观测肝功能的损伤与哪些因素相关。结果预防性使用护肝药物可使肝功能受损发生率降低(P=0.00)。化疗周期数与肝功能损伤相关(P=0.01)。结论晚期非小细胞肺癌患者化疗过程中,预防性使用护肝药物的患者可有效的降低肝功能损伤。Objective To study whether prophylactic use of the protection liver drugs can reduce the incidence of liver dysfunction in advanced non-small lung cancer patients when chemotherapy.Methods We retrospectively reviewed 138 cases advanced non-small cell lung cancer patients in Zhejiang Cancer Hospital.Whether prophylactic use of protection liver drugs before chemotherapy was studied.Chi-square test was used to analysis difference in liver dysfunction between whether the prophylactic use of protection liver drugs.What factors associated with liver injury were observed.Results Prophylactic use of liver drugs could reduce the incidence of impaired liver function （P =0.00,P ＜ 0.05）.Chemotherapy cycles had a relationship with liver dysfunction （P =0.01,P ＜ 0.05）.Conclucion Receiving protection liver drugs can effectively reduce incidence of impaired liver function in advanced non-small lung cancer patients when chemotherapy.

关 键 词：护肝药物 非小细胞肺癌 化疗 

分 类 号：R734[医药卫生—肿瘤]