女性抑郁症患者脑区静息态功能磁共振低频振幅特征及与症状严重程度的相关性  

Amplitude of low frequency fluctuation in female depression patients： a resting-state functional magnetic resonance imaging study

作　　者：阎锐[1] 姚志剑[1] 韦茂彬[2] 汤浩[1] 卢青[2] 

机构地区：[1]南京医科大学附属脑科医院抑郁症专科, 210029 [2] 东南大学学习科学研究中心

出　　处：《中华精神科杂志》2014年第4期195-199,共5页Chinese Journal of Psychiatry

基　　金：国家自然科学基金（81371522、61372032）;江苏省医学专项基金（BL2012052）;江苏省自然科学基金（BK2012740、BK20131074）;国家临床重点专科（卫生部医政司2011-873）;江苏省医学重点学科（江苏省科教处2011-12）

摘　　要：目的 探讨中青年女性抑郁症患者脑区自发性活动特征及与症状严重程度的相关性.方法 对14例女性抑郁症患者（患者组）和18名相匹配的健康对照者（对照组）,进行3.0T静息态功能磁共振扫描.比较两组被试者脑区低频振幅值,将差异有统计学意义的脑区低频振幅均值与症状严重程度进行相关分析.结果 患者组较对照组右小脑前叶[蒙特利尔神经病学研究所（MNI）坐标（x,y,z）：39,-54,-36,k=20]低频振幅值增高（t=3.678,P＜0.05）,左后扣带回[MNI坐标（x,y,z）：-6,-45,15,k=18]、左顶上小叶[MNI坐标（x,y,z）：-21,-78,48,k=20]低频振幅值降低（t=-3.967、-3.669,均P＜0.05,Alphasim矫正）.Pearson相关分析显示右小脑前叶低频振幅值与发作次数呈正相关（r =0.607,P=0.021）,与17项HAMD总分（r=-0.595,P=0.025）和认知障碍因子分（r=-0.542,P=0.045）呈负相关.结论 女性抑郁症患者存在静息态脑区局部神经元活动异常,其程度可能与症状严重程度及认知损害相关.Objective To explore energy feature of the spontaneous neural activity in young female depressive patients,and its correlation to the severity of depressive symptoms.Methods Fourteen female depressive patients and 18 healthy controls were scanned with 3.0 T MRI scanner.The difference with amplitude of low frequency fluctuation （ALFF） between both groups was compared with the t-test,and the correlation analysis between ALFF of brain regions with significant difference and the severity of depressive symptoms was conducted.Results Compared with healthy group,the depression group showed significantly increased ALFF in the right cerebellum anterior lobe （Montreal Neurological Institute（MNI） coordinates （x,y,z）：39,-54,-36; k =20; t=3.678,P 〈 0.05）,and decreased ALFF in the left posterior cingulate （MNI coordinates （x,y,z）：-6,-45,15; k =18） and the left superior parietal lobule （MNI coordinates （x,y,z）：-21,-78,48; k =20;t =-3.967,-3.669; both P 〈0.05; corrected by Alphasim）.The ALFF in the right cerebellum anterior lobe was positively correlated to the number of depressive episodes （r=0.607,P =0.021）,and negatively correlated to the HAMD17 total score and cognitive disturbance score （r =-0.595,P =0.025 ; r =-0.542,P =0.045,respectively）.Conclusion Abnormal brain activity could emerge in female depressive patients during resting-state,the level of ALFF may be associated with severity of depressive symptoms and cognitive disturbance.

关 键 词：抑郁症 磁共振成像 低频振幅 

分 类 号：R749.4[医药卫生—神经病学与精神病学]