肝动脉灌注栓塞术治疗肝癌的临床分析  

Analysis of transcatheter arterial chemoemblization in treatment of hepatocellular carcinoma

作　　者：杨广宁 刘群轶 翟鹏涛 

机构地区：[1]陕西省肿瘤医院微创介入科,西安710061

出　　处：《中国肿瘤临床与康复》2014年第8期956-958,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨肝动脉灌注栓塞术治疗肝癌的临床效果与安全性。方法选取50例肝癌患者作为研究组,所有患者行肝动脉灌注化疗后采取肿瘤血管末梢栓塞治疗;另选取经肝动脉灌注化疗的30例肝癌患者作为对照组,比较两组患者治疗后的瘤体客观反应率、甲胎蛋白(AFP)水平和生存率。结果研究组患者的生存率明显高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组患者的AFP下降率和肿瘤缩小率明显高于对照组,差异有统计学意义(P<0.05)。研究组患者发热发生率为58.0%,消化道反应发生率为62.0%;对照组发热发生率为30.0%,消化道反应发生率为33.3%,研究组患者不良反应发生率明显高于对照组(P<0.05)。结论肝动脉灌注栓塞术治疗肝癌的疗效明显优于单纯肝动脉灌注化疗法,且不良反应较轻,值得临床推广应用。Objective To investigate the clinical effects and safety of transcatheter arterial chemoembolization for treatment of hepatocellular carcinoma. Methods According to certain criteria to select 50 cases of patients with liver cancer as the study group, the tumor vascular peripheral embolization in the treatment of all patients underwent hepatic artery perfusion chemotherapy, in addition to select 30 cases of patients with liver cancer by hepatic artery infusion chemotherapy as control group, the objective response of tumor were compared between two groups after treatment, the levels of AEP and survival rate. Results in the study group, the survival rate of the patients was significantly higher than the control group, two groups of patients survival rate are significantly different （ P 〈 0.05 ） , after treatment of patients in the AFP group index decline rate and tumor size was significantly higher than that in control group, the difference between groups was significant （P 〈 0. 05 ） , there is statistical significance; feverresearch group rate of 58% , the digestive tract symptom occurrence rate was 62% ; the control group fever incidence was 30% , gastrointestinal disease incidence rate is 33.3%, rate of adverse reactions occurred in patients of the study groupwas significantly higher than the control group （ P 〈 0. 05 ）. Conclusion Transcatheter arterial infusion embolization in the treatment of liver cancer is better than that of hepatic artery perfusion chemotherapy, and the adverse reactions were tolerable, can be applied.

关 键 词：肝肿瘤 经肝动脉灌注栓塞术 治疗结果 安全性 

分 类 号：R735.7[医药卫生—肿瘤]