在沙漠干热环境中负重行军者血浆中NO和NOS与生理应激的关系  

Relation between Nitric Oxide and Nitric Oxide Synthase with physiological stress of marcher with load in dry heat environment of desert

作　　者：刘兵[1] 徐文[1] 石胜刚[1] 张雪玲[1] 吴志豪[1] 

机构地区：[1]中国人民解放军兰州军区疾病预防控制中心,甘肃省兰州市730020

出　　处：《职业与健康》2014年第16期2227-2229,共3页Occupation and Health

基　　金：全军青年基金(项目编号:96Q022)

摘　　要：目的探讨沙漠干热环境负重行军者NO和一氧化氮合酶(NOS)与生理应激的关系。方法 60名战士在沙漠干热环境中负重15 kg分别以3.5和5.0 km/h行军1、2、3 h,检测试验组和对照组战士血浆中NO含量和NOS活力、心律增值、肛温增值和积热指数。结果所有行军时间组NO(17.26~23.28μmol/L)含量均明显低于对照组(31.84μmol/L)(P<0.05),心率增值(7.6~23.9次/min)均明显高于对照(1.2次/min)(P<0.05)。15 kg负重3.5 km/h行军时,行军3 h组NO(17.26μmol/L)含量明显低于行军1 h组(22.62μmol/L)和2 h组(23.10μmol/L)(P<0.05);行军1 h组NOS(47.35 U/L)活力明显高于行军3 h组(40.90 U/L)和对照组(40.89 U/L)(P<0.05);行军3 h组肛温增值(0.17℃)明显高于行军1 h组(0.02℃)和对照组(0.00℃)(P<0.05);行军1和2 h组积热指数(-18.94^-18.31 kJ/m2)明显低于行军3 h组(22.67 kJ/m2)和对照组(0.41 kJ/m2)(P<0.05),行军3 h组积热指数明显高于对照组(P<0.05)。15 kg负重5.0 km/h行军时,行军2 h组NOS(39.44 U/L)活力明显低于对照组(40.89 U/L)和其他行军时间组(34.23~40.43U/L)(P<0.05);行军1 h组(23.9次/min)和3 h组(21.3次/min)心率增值明显高于行军2 h组(7.6次/min)(P<0.05);机体肛温随行军时间的延长而增高;各行军组积热指数(51.04~71.12 kJ/m2)明显高于对照组(0.41 kJ/m2)。结论在沙漠干热环境中行军者血浆中NO含量和NOS活力与热应激有关,沙漠干热环境劳动强度以不超过重度为宜,持续劳动时间不应超过2 h。[ Objective ] To explore the relation between nitric oxide （ NO ） and nitric oxide synthase （ NOS ） with physiological stress of marchers with load in dry heat environment of desert. [ Methods]60 soldiers with 15 kg marched in dry heat environment of des- ert at speed of 3.5 and 5.0 km/h for 1, 2 or 3 hours. NO, NOS, heart rate, rectal temperature and body heat storage index （ BHSI） of experimental and control group were detected. [ Results ] NO content in experimental groups （ 17.26-23.28 μmol/L） were lower than that in control group （ 31.84μmol/L ） （ P 〈 0.05 ） , the heart rates （ 7.6-23.9 beat/min ） were signifieantly higher than those in the control group （ 1.2 beat/min ） （ P 〈 0.05 ）. When marching at speed of 3.5 km/h, the NO content of 3 hours group （ 17.26 μ mol/L） was lower than that of 1 hour group （22.62 μmol/L） and 2 hours group （23.1 p, mol/L） （ P 〈0.05 ） ; the NOS vitality of 1 hour group （47.35 U） was higher than that in 3 hours group （40.91 U/L）and the control group （40.89 U/L） （ P 〈 0.05） ; the rectal temperature of 3 hours group （ 0.17 ℃ ） was obviously higher than that of 1 hour group （ 0.02 ℃ ） and the control group （ 0.00 ℃ ） （ P 〈0. 05 ） ; BHSI of 1 hour and 2 hours （ - 18.94- - 18.3 KJ/m2 ） were significantly less than that of 3 hours （ 22.67 KJ/m2 ） and control group （0.041 KJ/m2 ） / P 〈 0.05 ） ; BHSI of 3 hours was obviously more than that of the control group （ P 〈 0.05 ）. When marching at speed of 5.0 km/h, the NOS vitality of 2 hours group （ 39.44 U/L） was lower than that of other hours group （34. 23-40.43 U/L） and control group （40. 89 U/L） （P 〈0. 05） ; the heart rates of 1 hour group （23.9 beat/min） and 3 hours group （21.3 beat/min） were higher than that of 2 hours group （7.6 beat/min） （P 〈 0.05） ; the rectal temperatures increased with the increasing of marching time; the BHSI of experimental groups （51.04-71.12 KJ/m2）

关 键 词：干热 沙漠 一氧化氮 一氧化氮合酶 负重 行军 生理应激 

分 类 号：R594.1[医药卫生—内科学]