环戊通与阿托品用于儿童睫状肌麻痹验光的比较研究  

Comparison of cyclopentolate and atropine on cycloplegia in children

作　　者：王智[1] 肖启国[1] 费志刚[1] 

机构地区：[1]南华大学附属第二医院眼科,中国湖南省衡阳市421001

出　　处：《国际眼科杂志》2014年第8期1545-1547,共3页International Eye Science

摘　　要：目的：比较屈光不正儿童使用10g/L环戊通眼液和10g/L阿托品眼用凝胶后检影验光结果的差异情况。方法：对40例80眼、年龄4～12周岁的屈光不正儿童进行睫状肌麻痹验光,先用10g/L环戊通滴眼液点眼,每5min 1次,共3次,45min后行验光检查;3d后再使用10g/L阿托品眼用凝胶点眼,每天点眼3次,连续3d,于第4d复查验光。比较两种药物散瞳后检影验光屈光度值差异。结果：在4～8周岁组和9～12周岁组的近视眼组中,使用环戊通散瞳后检影验光屈光度平均值与使用阿托品散瞳后屈光度平均值差异无统计学意义（P=0.411,0.924）。在4～8周岁低度、中度和高度远视组中,环戊通散瞳后检影验光屈光度平均值明显低于阿托品散瞳后屈光度平均值,其差异均具有统计学意义（P=0.007,0.007,0.009）。9～12周岁低度远视眼组使用环戊通散瞳后检影验光屈光度平均值与使用阿托品散瞳后屈光度平均值差异均无统计学意义（P=0.592）,但在中度和高度远视组,其差异均具有统计学意义（P=0.039,0.012）。结论：10g/L环戊通眼液和10g/L阿托品眼用凝胶对低龄儿童都能起到使睫状肌调节放松的作用,但在远视儿童,两种药物的睫状肌麻痹效果仍具有一定的差异,因此在临床上应根据具体情况正确使用合适的睫状肌麻痹药物。AIM： To compare the effectiveness on 10g/L cyclopentolate and 10 g /L atropine on cycloplegia in children before optometry.METHODS： Eighty eyes of 40 children among 4-12 years old with refractive error were recruited in this study. 10 g /L cyclopentolate eye drops were topically administered once per 5min for 3 times and optometry was performed after45 min. Three days after that,10 g /L atropine sulfate eye gel then was used 3 times per day for consecutive 3d and again the refractive diopter was obtained at the 4thd. The differences of the results in retinoscopy refraction were compared between 10 g /L cyclopentolate eye drops and10 g /L atropine sulfate eye gel.RESULTS： Therefraction results of those given 10g/L cyclopentolate eye drops and 10 g /L atropine sulfate eye gel were no statistical different in both 4- 8 years group and 9- 12 years group with myopia（ ≤- 3. 00D）（ P = 0.411,0. 924）. The differences of refraction results of both the drugs were significant in 4- 8 years group with low hypermetropia, medium hypermetropia and high hypermetropia（P = 0. 007,0. 007,0. 009）. No significant difference was found in 9- 12 years group with low hypermetropia（ P = 0. 592）,given 10 g /L cyclopentolate eye drops and 10 g /L atropine sulfate eye gel,but the differences of refraction results of both the ophthalmicpreparations above were significant in 9- 12 years group with medium and high hypermetropia（P = 0. 039,0. 012）.CONCLUSION： Both 10g/L cyclopentolate eye drops and10 g /L atropine sulfate eye gel have the cycloplegic effects,but their cycloplegic effects are significant different among hypermetropia children. Thus,the reasonable cycloplegic should be chosen according to the specific situation.

关 键 词：环戊通 阿托品 睫状肌麻痹剂 验光 

分 类 号：R778[医药卫生—眼科]