轻度认知障碍患者脑脊液总Tau蛋白与β42淀粉样蛋白的Meta分析  

Meta analysis on the levels of total Tau protein and β-amyloid42 in cerebrospinal fluid in mild cognitive impairment patients

作　　者：郑媛[1] 温仲民[1] 

机构地区：[1]苏州大学附属第二医院神经内科,苏州215004

出　　处：《中国神经精神疾病杂志》2014年第6期341-347,共7页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的采用Meta分析方法研究轻度认知障碍(mild cognitive impairment,MCI)患者脑脊液总tau(totaltau,T-tau)蛋白及β淀粉样蛋白42(β-amyloid 42,Aβ42)水平的改变。方法计算机检索Pubmed、Cochrane临床试验数据库,Ovid全文电子期刊、中国知网全文数据库、维普中文期刊数据库及万方等数据库中关于MCI患者中脑脊液T-tau蛋白及Aβ42变化的病例-对照研究,采用Review Manager 5.2软件对数据进行Meta分析。结果共有17篇文献纳入分析。Meta分析结果显MCI患者脑脊液中T-tau蛋白水平显著高于对照组(MD=113.10,95%CI=87.93~138.26);而脑脊液中Aβ42水平明显低于正常对照组(MD=-146.50,95%CI=-178.70^-114.29),且两者的改变均有统计学差异(P<0.01)。结论 MCI患者脑脊液T-tau蛋白水平明显增高,而Aβ42水平明显下降。Objective To evaluate the changes of the level of cerebrospinal fluid T-tau protein andβ-amyloid 42 in mild cognitive impairment （MCI） patients. Methods Computer retrieval was preformed for cerebrospinal fluid （CSF） to-tal tau protein （T-tau） and β-amyloid 42 （Aβ 42） levels among MCI and healthy people in Pubmed, Cochrane Library, Ovid, CNKI, VIP Data and Wangfang Data. Meta-analyses were conducted on the T-tau and Aβ42 levels using Review Manager 5.2 software. Results Seventeen studies met inclusion criteria. Meta-analysis results showed that, CSF T-tau protein levels were significantly higher （MD：113.10;95%CI：87.93-138.26） and Aβ42 levels were significantly lower in the patients with MCI, （MD=-146.50;95%CI=-178.70～ -114.29） compared with the control group （P〈0.01）. Conclu-sions T-tau significantly increases while Aβ42 significantly decreases in the CSF in patients with MCI.

关 键 词：轻度认知障碍 META分析 Tau蛋白β-淀粉样蛋白 

分 类 号：R749.1[医药卫生—神经病学与精神病学]