超声引导下聚桂醇硬化治疗子宫肌瘤的疗效观察  

Safety and efficacies of ultrasound-guided sclerotherapy of uterine fibroids with lauromacrogol

作　　者：周霞[1] 谢阳桂[1] 崔琪[1] 许小平[1] 何茂胜 梁博[1] 

机构地区：[1]南通大学附属医院超声诊断科,江苏南通226001

出　　处：《中华医学杂志》2014年第28期2204-2206,共3页National Medical Journal of China

基　　金：南通市社会发展基金项目（BK2011074）

摘　　要：目的 探讨超声引导下聚桂醇硬化治疗子宫肌瘤的疗效.方法 对102例育龄期子宫肌瘤患者的1 13个肌瘤行超声引导下聚桂醇硬化治疗,于术前及术后1、3、6、12个月行常规超声及彩色多普勒超声检查,比较治疗前后肌瘤体积及血供的变化;并以症状严重性评分调查问卷形式评估患者临床症状的变化.结果 治疗后1、3、6及12个月,肌瘤体积较术前分别平均缩小40％、47％、58％及70％（P＜0.05）;治疗前后患者症状严重性评分之间的差异有统计学意义（P=0.000）;术中及术后无严重并发症发生.结论 超声引导下聚桂醇硬化治疗子宫肌瘤是安全、有效的微创治疗子宫肌瘤的方法,值得临床推广应用.Objective To evaluate the safety and efficacies of ultrasound-guided sclerotherapy of uterine fibroids with lauromacrogol.Methods A total of 102 consecutive premenopausal women with 113 uterine fibroids were enrolled.The treatment of lauromacrogol was performed under the guidance of ultrasound.Both conventional and color Doppler ultrasound were performed before treatment and at Month 1,3,6 and 12 after treatment.The changes of tumor volume reductions and vascular flow were analyzed and compared.And the alteration of symptoms was evaluated by the symptom severity score （SSS） questionnaire.And adverse events were also assessed during and after treatment.Results At Month 1,3,6 and 12 after treatment,the mean volume of fibroids decreased by 40％,47％,58％ and 70％ respectively.And the differences had statistical significance before and after treatment （P ＜ 0.05）.The clinical symptoms alleviated greatly or even disappeared.And the differences in SSS before and after treatment were also statistically significant （P =0.000）.There was no onset of severe adverse events.Conclusion Both safe and efficacious,ultrasound-guided sclerotherapy of uterine fibroids with lauromacrogolis offers an alternative option for patients with fertility requirements.

关 键 词：子宫肌瘤 聚桂醇 硬化治疗 

分 类 号：R737.33[医药卫生—肿瘤]