Double-stranded DNA in exosomes： a novel biomarker in cancer detection  

作　　者：Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden 

机构地区：[1]Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, Cell and Developmental Biology, Weill Cornell Medical Col- lege, New York, NY 10021, USA [2]Department of Pediatric Hematology and Ontology, Hannover Medical School, Hannover 30625, Germany [3]Genomie Resource Cote Facility, Weill Cornell Medical College, New York, NY 10065, USA [4]Department of Pathology, lcahn School of Medi- cine at Mount Sinai, New York, NY 10029, USA [5]Bioinformatics Labora- tory, Department of Medicine, lcahn School of Medicine at Mount SinaL One Gustave L Levy Place, New York, NY 10029, USA [6]Microscopy Facil- ity, Hershey Building Room 103, Laboratory of Cancer Systems Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA [7]Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY 10065, USA [8]Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA [9]Department of Molecular Hematopoi- esis, Hannover Medical School, Hannover 30625, Germany [10]Department of Medicine, Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical College, New York, NY 10065, USA

出　　处：《Cell Research》2014年第6期766-769,共4页细胞研究（英文版）

摘　　要：Exosomes, small membrane vesicles （30-100 nm） of endocytic origin secreted by most cell types, contain functional biomolecules, which can be horizontally transferred to recipient cells [1]. Exosomes bear a specific protein and lipid composition, and carry a select set of functional mRNAs and microRNAs [2]. Recently, our group has shown that c-Met shed in exosomes can promote a proangiogenic and prometastatic phenotype in bone marrow-derived progenitor cells during melanoma progression [3]. In previous research, retrotransposon RNA transcripts, single-stranded DNA （ssDNA）,

关 键 词：生物标记物 双链DNA 癌症检测 microRNA SSDNA 单链DNA 细胞类型 生物分子 

分 类 号：Q523[生物学—生物化学] P618.13[天文地球—矿床学]