microRNA在肝脏非可控病毒感染性炎性反应恶性转化过程中的作用  

The role of microRNA in virus-infection non-resolving inflammation related hepatocellular malignant transformation

作　　者：范瑞琦[1] 揭克敏[1] 肖影群[2] 刘卓琦[1] 王蒙蒙[1] 罗达亚[1] 

机构地区：[1]南昌大学基础医学院生物化学与分子生物学教研室,江西南昌330006 [2]南昌大学附属感染病医院病理科,江西南昌330002

出　　处：《基础医学与临床》2014年第8期1133-1137,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(30860319;81160248;81360313);江西省研究生创新专项资金(YC2013-S006)

摘　　要：非可控性炎性反应是指机体在感染或非感染因素的作用下,炎性反应无法从组织损伤模式转变至平衡稳定,而导致炎性反应持续进行的状态。miRNA与多种炎性因子相互作用,在肝脏非可控病毒感染性炎性反应恶性转化过程中发挥了重要的调控作用。深入研究miRNA与炎性因子在该过程中的作用将有助于揭示炎性反应与肿瘤的关系,为临床治疗非可控性炎性反应恶性转化类疾病提供新的思路。Non-resolving inflammation refers to a long-term non-homeostasis status under the action of infectious or noninfectious factors. There are studies showing that miRNA interacts with inflammation factors playing critical roles in the process of nonresolving inflammation related hepatocellular malignancy. Further investigation on the relationship between miRNA and inflammation factors during this process will be of great value to uncover the relationship between inflammation and tumor and innovate new therapy methods for nonresolving inflammation related malignant diseases.

关 键 词：非可控性炎性反应 MICRORNA 慢性病毒性肝炎 肝纤维化 肝细胞癌 

分 类 号：R735.7[医药卫生—肿瘤]