肠道菌群失调与结肠癌发生发展之间关系的研究进展  

Intestinal microbiota dysbiosis associated with the development of colon cancer: progress and prospects

作　　者：王生[1,2] 黄晓星[1,2] 余鹏飞[3] 徐小涛[1,2] 王一飞[1,2] 刘莉[1,2,4] 梅其炳[1,2,4] 

机构地区：[1]中国医药工业研究总院,上海200040 [2]上海医药工业研究院创新药物与制药工艺国家重点实验室,上海200437 [3]第四军医大学西京消化病医院,陕西西安710032 [4]上海市生物物质成药性评价专业技术服务中心,上海200437

出　　处：《中国药理学通报》2014年第8期1045-1049,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81370564)

摘　　要：肠道菌群是机体重要的组成部分,正常状况下肠道菌群保持稳态,在促进营养物质消化吸收、维持肠道正常生理功能、调节机体免疫等众多生命活动中发挥重要的作用。但当体内外环境发生改变,如年龄、饮食习惯、肥胖等代谢性疾病以及抗生素等药物均会造成菌群失调。近年来,很多研究发现肠道菌群失调可以引发多种疾病,其中结肠癌的发生、发展与肠道菌群失调关系密切。同时,有研究资料表明,通过改善肠道菌群的失调状态可降低结肠癌的发生率和抑制结肠癌的生长恶化,但是具体的作用机制尚无清晰的认识。该文就近年来国内外关于肠道菌群失调与结肠癌发生、发展研究的有关热点问题及治疗进行概述,为肠道菌群研究和结肠癌的治疗提供理论参考。Intestinal microflora is an important part of the organ-ism, promoting digestion and absorption of nutrients, maintaining intestinal normal physiological function, regulating immune sys-tem. Intestinal microflora maintains steady state under normal conditions, but intestinal microbiota dysbiosis occurs when surrounding environment c hanges, such as age, diet, obesity and other metabolic diseases as well as antibiotics. Many recent studies have found intestinal flora could cause a variety of disea-ses, and colon cancer is closely related with intestinal microbiota dysbiosis. Some researches suggest improving the intestinal flora dysbiosis can reduce the incidence of colon cancer and inhibit the growth and the worsening of colon cancer. However, under-lying mechanisms remain unknown. So this article summarizes the research progress on the development of colon cancer and in-testinal microbiota dysbiosis, in order to provide reference for re-search on intestinal flora and colon cancer treatment.

关 键 词：肠道菌群 肥胖 菌群失调 细菌移位 细菌代谢 结肠癌 

分 类 号：R-05[医药卫生]