ABCB1基因多态性对阿片类药物依赖和镇痛耐受的影响及机制  

Impact of ABCB1 gene polymorphism on opioid dependence and analgesic tolerance

作　　者：甘陈灵 陈中国[2] 何玲[1] 刘景根[2] 

机构地区：[1]中国药科大学药理学教研室,江苏南京210009 [2]中国科学院上海药物研究所新药研究国家重点实验室,上海201203

出　　处：《中国药理学通报》2014年第8期1055-1058,共4页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展计划(973计划)资助项目(No2013CB835100);国家十二五"新药创制"科技重大专项基金资助项目(No 2012ZX09301001-005);十二五国家科技支撑计划重大专项资助(No 2012BAI01B00);国家自然科学基金(No 81130087;91232716);上海市科学技术委员会基金项目(No 13JC140680)

摘　　要：药物依赖是当前神经科学研究的热点问题,其病因错综复杂。近年来,药物依赖与ATP结合盒B亚家族成员1转运蛋白(ATP-binding cassette subfamily B member 1 transporter,ABCB1)基因多态性的关系越来越受到关注,特别是位于26号外显子区域的3435C>T。该文就阿片类药物依赖和镇痛耐受与ABCB1基因多态性的关系进行综述,对于深入阐明药物依赖的机制以及指导美沙酮个体化治疗具有重要意义。Drug dependence has been a hot topic in neuroscience research due to its complicated pathogenesis. Recently, huge scientific efforts have been continuously put into understanding the association between drug dependence and polymorphism in ATP-binding cassette subfamily B member 1 transporter （ ABCB1 ） gene, especially a mutation in exon 26 at position 3435 （3435C＆gt;T）. This article reviews the relationship between opioid dependence and analgesic tolerance and ABCB1 gene pol-ymorphism, which will shed light on the underlying mechanisms of drug dependence and optimal MMT programs for individuals.

关 键 词：药物依赖 ABCB1 基因多态性 镇痛耐受 美沙酮替代治疗 

分 类 号：R-05[医药卫生]