PTTG和VEGF在肺癌组织中的表达及其意义  

作　　者：张泳[1] 王建华[1] 李迎春[2] 

机构地区：[1]陕西中医学院附属医院外三科,陕西712000 [2]解放军第323医院护理部,710054

出　　处：《当代医学》2014年第24期4-5,共2页Contemporary Medicine

基　　金：陕西省教育厅项科研项目(2010JK505)

摘　　要：目的探讨垂体瘤转化基因(pituitary tumor transforming gene,PTTG)与血管内皮生长因子(vascular endothelial growth factor,VEGF)在肺癌组织中的表达及其意义。方法采用免疫组化SP法检测PTTG与VEGF在人肺癌组织中表达及其与临床病理参数之间的关系。结果 PTTG与VEGF在人肺癌组织中的表达率分别为76.67%(46/60)和91.67%(55/60)明显高于其在癌旁组织中的表达,且差异具有统计学意义(P<0.05);PTTG与VEGF在肺癌组织中的表达与患者的性别、年龄、肿瘤大小无关,与TNM分期和淋巴结转移密切相关,差异有统计学意义(P<0.05);PTTG与VEGF表达呈正相关。结论 PTTG在肺癌组织中的表达可能与血管生成相关。Objective To explorer PTTG and VEGF expression in lung cancer tissue and its significance.Methods Using immunohistochemical SP method to detect the PTTG and VEGF expression in human lung cancer tissues and the relationship between the clinical pathological parameters.Results The Expression of PTTG and VEGF in human lung cancer rates were 76.67% （46/60） and 91.67% （55/60） respectivelyand significantly higher than noncancerous tissue, （P＆lt;0.05） and the difference is statistically significant; PTTG and VEGF expression in lung cancer tissue has nothing to do with the patient＆#39;s gender, age, tumor size,and is closely related to the TNM stages and lymph node metastasis, （P＆lt;0.05）and the difference is statistically significant; The expression of PTTG and VEGF were positively correlated.Conclusion PTTG expression may be associated with angiogenesis in lung cancer tissue and it is expected to become the new lung cancer markers.

关 键 词：肺癌 PTTG VEGF 分子标志物 

分 类 号：R734.2[医药卫生—肿瘤]