利培酮合并丙戊酸钠对精神分裂症患者攻击行为疗效的对照研究  

The comparative study of the efficacy of risperidone combined with valproate sodium on the aggressive behavior of the patients with schizophrenia

作　　者：王桂丽[1] 付培鑫[1] 李新英[1] 林祥吉[1] 纪青松[1] 李振江[1] 

机构地区：[1]北京市安康医院,北京101300

出　　处：《中国药物滥用防治杂志》2014年第4期200-202,共3页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨丙戊酸钠对精神分裂症患者攻击行为的疗效。方法:将60例精神分裂症患者随机分为研究组、对照组,研究组采用利培酮合并丙戊酸钠治疗,对照组采用利培酮单一治疗,采用阳性和阴性症状量表(PANSS)、外显攻击行为量表(MOAS),在入组时以及第1、2、4、8周末进行评定,并进行统计分析。结果:两组PANSS和MOAS评分在第1、2、4周末和第8周末较入组时均显著降低(P<0.01或<0.05)。除第1周末外,在各时点PANSS和MOAS评分,研究组均显著低于对照组(P<0.O1)。不良反应总发生率两组间差异无统计学意义(P>0.05)。结论:丙戊酸钠与利培酮联合治疗精神分裂症,不但能增强单一使用利培酮的疗效,而且能有效控制攻击行为。Objective： To explore the efficacy of valproate sodium on the aggressive behavior of the patients with schizophrenia.Methods： A total of 60 inpatients with schizophrenia were randomly assigned to two groups： the study group and the controlled group,and the former was treated with risperidone combined with valproate sodium,while the latter with risperidone alone. The positive and negative syndrome scale（ PANSS）,Modified Overt Aggression Scales（ MOAS） were comparable for the two groups prior to the therapy and in weeks 1,2,4,8. Results： The PANSS and MOAS total scores of the two groups were all significantly lower than prior to the therapy at the at the endpoint of weeks 1,2,4,8（ P〈0. 01 or P〈0. 05）. The PANSS and MOAS scores of the study group were significantly lower than the controlled group at the endpoint of weeks 2,4,8（ P〈0. 01）. There were no significance in the incidence rate of adverse events in the two groups（ P〉0. 05）. Conclusion： The risperidone with valproate sodium can be more effective in treatment of schizhophrenia than the risperidone alone,also can control the aggressive behavior more effectively.

关 键 词：精神分裂症 攻击行为 丙戊酸钠 利培酮 

分 类 号：R749.3[医药卫生—神经病学与精神病学]