急性脑梗死后白细胞介素6与神经功能缺损评分的相关性及β-七叶皂甙钠的治疗作用  

Association between serum IL-6level and nerve function score in AIS patients and effect ofβ-aescinum natrium on AIS

作　　者：庄丽丽[1] 李晓宾[1] 李传玲[1] 崔晓[1] 郭靖[1] 鹿寒冰[1] 安晓雷[1] 

机构地区：[1]徐州市中心医院神经内科,221009

出　　处：《中华老年心脑血管病杂志》2014年第8期840-842,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：徐州市科技计划项目(XZZD1123)

摘　　要：目的观察急性脑梗死后血清白细胞介素6(IL-6)与神经功能缺损程度评分的动态变化,探讨IL-6对急性脑梗死后神经功能恢复的影响及β-七叶皂甙钠治疗急性脑梗死的作用机制。方法选择急性脑梗死患者63例,随机分为对照组30例和治疗组33例,对照组予以脑梗死常规治疗,治疗组在常规治疗基础上加用β-七叶皂甙钠,在脑梗死后1、5、14d进行血清IL-6测定和美国国立卫生研究院卒中量表(NIHSS)评分。另选取健康体检者30例为正常组,清晨测定血清IL-6。结果治疗组和对照组患者脑梗死后1、5、14dIL-6水平较正常组明显升高,差异有统计学意义(P<0.01);治疗组脑梗死后14d血清IL-6水平明显低于对照组[(13.33±2.82ng/L)vs(15.25±4.65)ng/L,P<0.05];对照组和治疗组脑梗死后14d神经功能缺损评分较1、5d明显改善,差异有统计学意义(P<0.01);治疗组脑梗死后14d神经功能缺损评分较对照组明显降低[(9.03±2.28)分vs(10.38±2.30)分,P<0.05];脑梗死患者血清IL-6水平与神经功能缺损评分呈正相关(r=0.888,P<0.01)。结论急性脑梗死后血清IL-6水平与神经功能缺损密切相关,β-七叶皂甙钠可能通过抑制血清IL-6的增高而改善神经功能。Objective To study the association between serum IL-6level and nerve function score and the effect ofβ-aescinum natrium on AIS by observing their dynamic changes in AIS patients.Methods Sixty-three AIS patients were randomly divided into control group（n=30）and treatment group（n=33）.Patients in control group received routine treatment and those in treatment group underwent combined routine andβ-aescinum natrium treatment.Their serum IL-6level was measured on days 1,5and 14 after ischemic stroke and their nerve function was scored at the corresponding time points.Thirty healthy subjects undergoing physical examination served as a normal group and their serum IL-6level was measured at morning.Results The serum IL-6level was significantly higher in treatment group and control group than in normal group on days 1,5and 14 after ischemic stroke,and significantly lower in treatment group than in control group on day 14 after ischemic stroke（13.33±2.82ng/L vs 15.25±4.65ng/L,P〈0.05）.The NIHSS score of nerve function was higher in treatment group and control group on day 14 than on days 1and 5after ischemic stroke（P〈0.01）,and significantly lower in treatment group than in control group on day 14 after ischemic stroke（9.03±2.28 vs 10.38±2.30,P〈0.05）.The serum IL-6level was positively related with the NIHSS score of nerve function in AIS patients（r=0.888,P〈0.01）.Conclusion The serum IL-6level is closely associated with the nerve function score andβ-aescinum improves the nerve function by reducing the serum IL-6level in AIS patients.

关 键 词：脑梗死 白细胞介素6 神经系统疾病 七叶素 

分 类 号：R743.33[医药卫生—神经病学与精神病学]