Bio-Oss与表面改性后钛铌锆锡修复种植体周围骨缺损的组织学研究  

Study of bone regeneration surrounding Ti-24Nb-4Zr-8Sn modified and Bio-Oss implants by micro-arc oxidation and alkali-heat treatment

作　　者：韩雪[1,2] 刘洪臣[2] 王东胜[2] 鄂玲玲[2] 吴霞[2] 李述军 周威[1] 

机构地区：[1]解放军第三零九医院口腔科,副主任医师北京100091 [2]解放军总医院口腔医学研究所,博士后北京100853 [3]中科院金属研究所,研究员辽宁110016

出　　处：《口腔颌面修复学杂志》2014年第4期207-209,共3页Chinese Journal of Prosthodontics

基　　金：国家自然科学基金(项目编号:81271180)

摘　　要：目的:探讨经微弧氧化碱热处理(Micro-arc oxidation and alkali heatment,MAH)后Ti-24Nb-4Zr-8Sn合金和Bio-Oss修复种植体周围骨缺损的愈合情况。方法:Ti-24Nb-4Zr-8Sn合金制备成圆柱状样本,分二组(光滑表面和微弧氧化碱热组)进行表面处理。拔除犬下颌第二、三、四前磨牙,拔牙窝周围制备骨缺损,将两组种植体随机植入拔牙窝内,缺损区放置Bio-Oss,1个月后组织学染色观察种植体周围骨缺损的修复情况。结果:微弧氧化碱热种植体周围及Bio-Oss颗粒表面类骨质多而密,种植体表面可见大量新生骨的存在,BIC达25.68±5.2%。光滑表面种植体周围的骨缺损区,Bio-Oss颗粒周围新生骨较少,种植体表面未见新生骨的存在。结论:MAH和Bio-Oss可促进种植体周围骨缺损的修复及种植体骨整合。Objective： To investigate the bone regeneration surrounding Ti-24Nb-4Zr-8Sn modified and Bio-Oss implants by micro-arc oxidation and alkali-heat treatment（MAH）. Methods： Cylinder-like specimens（3mm in diameter and10 mm in height） were made from Ti2448 alloy, and divided into two groups with different surface treatments： polished（Ti2448）, and micro-arc oxidation and alkali-heat treatment（MAH-Ti2448）. Bone defects were obtained by extracting mandible second, third, fourth premolars of three adult dogs. The cylinder implant specimens were placed into the extracted sockets, and then the Bio-Oss was placed into the bone defects. After 4 weeks, the bone structure were evaluated through histological microscopy. Results： After 4 weeks, bone defects surrounding MAH-Ti2448 and Bio-Oss were filled with osteoid and newly formed bones in conjunction with the implants. Few osteoid was observed around Bio-Oss, and osseo-integration was not formed in the implant-bone interface of the polished Ti 2448 specimens. Conclusions： MAH surface treatment and Bio-Oss could enhance the process of bone formation and improve the implant-bone integration.

关 键 词：钛合金 微弧氧化 碱热处理 BIO-OSS 骨再生 

分 类 号：R783.6[医药卫生—口腔医学]