Ⅰ型干扰素免疫应答作用机制研究进展  

Advances in type I interferon-mediated immune response mechanism

作　　者：张军楠[1] 邵杰[1] 梁争论[1] 

机构地区：[1]卫生部生物技术产品检定方法及标准化重点实验室,中国食品药品检定研究院,北京100050

出　　处：《微生物学免疫学进展》2014年第3期54-58,共5页Progress In Microbiology and Immunology

基　　金：国家高技术研究发展计划(863计划)项目(2012AA02A402)

摘　　要：I型干扰素(IFN-Ⅰ)是机体固有免疫应答的一类重要的细胞因子,具有广谱的抗病毒及抗肿瘤等作用。近年来IFN-Ⅰ成为病毒学、疫苗学及肿瘤学等研究的热点,对干扰素诱导基因(ISGs)的功能研究进一步揭示了其抗病毒以及抗肿瘤的作用机制。麻疹病毒、流感病毒和肠道病毒71型等病毒均可通过与IFN-Ⅰ或其上、下游调节因子结合阻断IFN-Ⅰ信号通路,从而逃逸IFN-Ⅰ的抗病毒作用,这对病毒性疾病的防治是新的挑战。近期研究发现IFN-Ⅰ是疫苗诱导抗体产生的必要信号,同时参与调节T、B细胞的活化过程,在免疫应答过程中发挥关键作用。对IFN-Ⅰ免疫应答作用机制研究进行了综述。TypeⅠIFN（ IFN-Ⅰ） is a class of important cytokines in the innate immune response,with broad effectiveness in antiviral and anticancer therapy. Recently,IFN-Ⅰhas become hotspots in virology,vaccinology and oncology. The antiviral and antitumor mechanisms were further revealed through functional studies on interferon induced downstream genes ISGs. Some viruses such as measles,influenza and enterovirus 71 could block IFN-Ⅰsignaling pathway through combining with IFN-Ⅰor its upstream / downstream regulatory factors to further escape from antiviral activity of IFN-I,which proposes a new challenge for the prevention and treatment of viral diseases. IFN-Ⅰplays a critical role in immune response. They are the necessary signals in antibody production after vaccination and regulate T and B cell activation. This review summarizes the immune response mechanism of IFN-Ⅰ.

关 键 词：IFN-Ⅰ 免疫应答 病毒 疫苗 

分 类 号：R392.11[医药卫生—免疫学]