鼻咽癌组织中FOXC1的表达及其与E-cadherin关系的初步研究  

Expression of FOXC1 and its relationship with E-cadherin in nasopharyngeal carcinoma tissues

作　　者：刘鹏[1,2] 谭盛葵[3] 肖胜军[4] 易世江[1,2] 欧阳磊[1,2] 侯巧燕[4] 熊伟明[1,2] 雷迅[1,2] 

机构地区：[1]桂林医学院附属医院耳鼻咽喉-头颈外科 [2]桂林医学院耳鼻喉研究所,广西桂林541004 [3]桂林医学院公共卫生学院 [4]桂林医学院附属医院病理科

出　　处：《临床耳鼻咽喉头颈外科杂志》2014年第15期1109-1112,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨FOXC1在鼻咽癌组织中的表达情况及与临床病理特征的关系,并分析其与E-cadherin的相关性。方法:应用免疫组织化学SP法检测FOXC1在鼻咽癌组织和鼻咽黏膜炎性组织中的表达。结果:①鼻咽癌细胞中FOXC1表达主要定位于细胞核,阳性率为85.3%(81/95),明显高于鼻咽黏膜炎性组织中的阳性率59.4%(19/32),两者比较差异有统计学意义(P<0.05)。②FOXC1的表达与鼻咽癌患者性别、年龄、肿瘤的临床分期及淋巴结转移等临床病理指标无明显相关性(P>0.05)。③鼻咽癌组织中FOXC1的表达与E-cadherin表达下调存在相关性(P<0.05)。结论:FOXC1可能在鼻咽癌的发生中发挥重要作用,其与E-cadherin表达下调可能有一定的相关性,可能通过调控E-cadherin的表达,进而参与鼻咽癌发生上皮-间质转化的过程。Objective：To investigate the significance and relationship between the expression of FOXC1and clinicopathological features,and to explore its correlation with E-cadherin.Method：Immunohistochemical SP method was used to detected the expression of FOXC1in nasopharyngeal carcinoma tissues and nasopharyngitis tissues.Result：①Immunoreaction to FOXC1was mainly located in nucleus of nasopharyngeal carcinoma cells.The positive expression rate of FOXC1in nasopharyngeal carcinoma tissues was 85.3%（81/95）,which was significantly higher than that in nasopharyngitis tissues（59.4%）（P＆lt;0.05）.②The expression of FOXC1 was not related to patients’ age and gender,clinical stage of cancer and lymph node metastasis（P＆gt;0.05）.③There was a correlation between the expression of FOXC1and down-regulated expression of E-cadherin in nasopharyngeal carcinoma tissues（P＆lt;0.05）.Conclusion：FOXC1may play an important role in generation and progression of nasopharyngeal carcinoma,there may be a correlation between the expression of FOXC1and down-regulated expression of E-cadherin,also FOXC1may play an important role in the process of EMT in nasopharyngeal carcinoma by regulating E-cadherin.

关 键 词：鼻咽肿瘤 上皮型钙黏蛋白 叉头框转录因子C1 组织芯片 免疫组织化学 

分 类 号：R739.63[医药卫生—肿瘤]