非小细胞肺癌组织中Napsin-A表达与EGFR基因的相关性研究  

Study on the correlation of Napsin-A expression and EGFR genes in non-small cell lung cancer tissue

作　　者：韩志刚[1] 俞婷婷[1] 申红丽[1] 阿力木江.赛提瓦尔地 

机构地区：[1]新疆医科大学附属肿瘤医院肺内一科,新疆乌鲁木齐830011

出　　处：《实用临床医药杂志》2014年第13期1-3,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11321273)

摘　　要：目的探讨非小细胞肺癌(NSCLC)组织中Napsin-A表达与表皮生长因子受体(EGFR)基因的关系。方法采用免疫组织化学法检测89例肺腺鳞癌组织中Napsin-A的表达情况,并用ARMS试剂盒检测上述组织中EGFR基因的表达情况,分析Napsin-A的表达与EGFR基因的关系。结果在NSCLC组织中,腺癌和鳞癌的Napsin-A阳性率分别为96.2%和5.6%,两者比较差异有统计学意义。肺腺癌组织中,EGFR基因突变率为54.7%,而Napsin-A表达阳性者的突变率高达100.0%;肺鳞癌组织中,EGFR基因突变率为5.6%,而Napsin-A表达阳性者的突变率为50.0%,两者比较,差异有统计学意义。结论Napsin-A在肺腺癌组织中高表达,且在腺鳞癌中表达阳性者EGFR基因突变率较高,Napsin-A表达阳性者可建议行EGFR基因检测。Objective To explore the relationship between Napsin-A expression and epider-mal growth factor receptor （EGFR）genes in non-small cell lung cancer （NSCLC）tissue.Methods Napsin-A expression in 89 adenosquamous carcinoma tissues of the lung was detected by immunohisto-chemistry,and the expression of EGFR genes in the tissues above was also detected by ARMS kit.The relationship between Napsin-A expression and EGFR was analyzed.Results The Napsin-A positive rates of adenocarcinoma and squamous carcinoma in NSCLC tissue were 96.2% and 5.6%,respec-tively,and there was statistical significance between them.The mutation rate of EGFR gene in lung adenocarcinoma tissue was 54.7%,while that of the patients with positive Napsin-A expression came up to 100.0%.The mutation rate of EGFR gene in lung squamous tissue was 5.6%,while that of the patients with positive Napsin-A expression came up to 50.0%,in which significant difference was presented by comparison to them.Conclusion Napsin-A is highly expressed in lung adenocarcinoma tissue,and the EGFR mutation rate of patients with positive expression in adenosquamous carcinoma is also high.Hence,for the patients with positive Napsin-A expression,it should be recommended to de-tect EGFR genes.

关 键 词：Napsin-A 非小细胞肺癌 表皮生长因子受体 腺癌 鳞癌 

分 类 号：R734.2[医药卫生—肿瘤]