Bmi-1、P16蛋白在乳腺癌组织中的表达及相关性研究  

Expressions and Relevance of Bmi-1 and P16 Expressions in Patients with Breast Cancer

作　　者：胡继卫[1] 孙志国[1] 马杰[1] 张景华[1] 张顺礼 李文建[1] 

机构地区：[1]河北省唐山市人民医院乳腺科,河北唐山063001

出　　处：《实用临床医药杂志》2014年第13期33-36,50,共5页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金项目(11321272)

摘　　要：目的探讨Bmi-1、P16蛋白在乳癌组织中的表达及意义,以及与ER、PR、HER-2的关系。方法应用免疫组织化学SP法检测80例乳腺癌中Bmi-1、P16蛋白的表达情况,并分析其相关性。结果在乳腺癌组织中,Bmi-1蛋白高表达,并与临床分期、组织学分级、淋巴结转移呈正相关(P<0.05),与患者年龄、肿瘤大小、ER、PR、HER-2无关(p>0.05)。与正常对照组相比,乳腺癌组织中P16蛋白低表达,并与临床分期、组织学分级、淋巴结转移呈负相关(P<0.01),但与HER-2表达显著相关(P<0.05),与患者年龄、肿瘤大小、ER、PR无关(P>0.05)。结论 Bmi-1、P16在乳腺癌的复发、转移中发挥重要作用。联合检测Bmi-1、P16可作为预测乳腺癌预后的重要生物学指标。Objective To explore the expressions Bmi-1 and P16 and their significances of in patients with breast cancer and to analyze their relationships with biomarkers,such as ER,PR and HER-2.Methods The expressions of Bmi-1 and P16 were detected by immunohistochemical SP method in 80 patients with breast cancer and their relationships were evaluated.Results The expres-sion of Bmi-1 was positively related with the TNMstaging,histological degrees and lymph node metas-tasis （P 〈0.05）,but had no association with age,tumor volume as well as the expressions of ER,PR and HER-2 （P 〉0.05）.Compared with normal tissues,the low expression of P16 was in reverse rela-tionship with the TNMstaging,histological degrees and lymph node metastasis （P 〈0.05）,related with HER-2 expression （P 〈0.05）,but had no association with age,tumor volume as well as the ex-pressions of ER and PR （P 〉0.05）.Conclusion The expressions of Bmi-1 and P16 proteins play an important role in the recurrence and metastasis of breast cancer,and their combined detection can be used as an important indicator for the prognosis of breast cancer.

关 键 词：乳腺癌 免疫组织化学 BMI-1蛋白 P16 蛋白 

分 类 号：R737.9[医药卫生—肿瘤]