肉芽肿性小叶性乳腺炎与抗精神病药物的相关性探讨  

Correlation of granulomatous lobular mastitis with psychotropic drugs

作　　者：程涓[1] 丁华野[2] 杜琳[3] 杜玉堂[4] 戴欣[1] 

机构地区：[1]北京中医药大学东直门医院病理科,北京100700 [2]北京军区总医院病理科,北京100700 [3]北京中医药大学东直门医院针灸科,北京100700 [4]北京中医药大学东直门医院乳腺科,北京100700

出　　处：《诊断病理学杂志》2014年第7期448-450,共3页Chinese Journal of Diagnostic Pathology

基　　金：北京中医药大学2013年度自主选题资助项目(2013-JYBZZ-JS-147)

摘　　要：目的 分析肉芽肿性小叶性乳腺炎与服用抗精神病药物之间的相关性.方法 收集8例此类病例,对其临床和组织病理学资料进行回顾性分析.结果 8例肉芽肿性小叶性乳腺炎患者年龄为19 ～ 34岁,其中5例未生育,3例有生育史,4例血清泌乳素升高.因抑郁/焦虑或精神分裂症服用抗精神病药物2～ 17年.大体检查乳腺肿块直径2 ～ 12 cm,与周围组织界限不清,切面见小脓腔或小囊腔,直径0.1 ～0.5 cm,腔内有灰白或淡黄色分泌物;镜下观察8例均有肉芽肿性小叶性乳腺炎的典型表现.结论 肉芽肿性小叶性乳腺炎可能与服用抗精神病药物相关,准确诊断有助于临床针对性治疗和减少复发,对提高患者生活质量具有积极意义.Objective To analyze the correlation between the granulomatous lobular mastitis and taking psychotropic drugs.Methods The 8 such cases were collected,and the clinical and pathological data were retrospectively analyzed.Results 8 cases of granulomatous lobular mastitis patients aged 19 ～ 34 years; 5 cases was infertile women,and 3 cases presented with a reproductive history; 4 cases was associated with increased serum prolactin.Because of depression / anxiety or schizophrenia psychotropic drugs had be taken for 2 ～ 17 years.Gross examination showed that breast tumor sized 2 ～ 12 cm in diameter,without boundaries with surrounding tissue; cutting section showed small abscess or follicular cavity,with the diameter of 0.1 ～ 0.5 cm,and a grey or light yellow secretion.Microscopically,8 patients had typical findings of granulomatous lobular mastitis.Conclusions The granulomatous lobular mastitis may be associated with psychotropic drugs.It is helpful to the accurate diagnosis for clinical targeted therapy,to reduce recurrence,and to improve the quality of life of patients.

关 键 词：肉芽肿性小叶性乳腺炎 抗精神病药物 高泌乳素血症 

分 类 号：R737.9[医药卫生—肿瘤]