非小细胞肺癌IL-13R_α2 SNP基因多态性及其临床意义  

Polymorphism of IL-13R_α2 SNP and its clinical significance in non-small cell lung cancer

作　　者：吴慧娟[1,2] 吴红波[1,2] 邹宏志[1,2] 陈利娟[1,2] 赵艳秋[1,2] 

机构地区：[1]郑州大学附属肿瘤医院 [2]河南省肿瘤医院内科,河南省450008

出　　处：《江苏医药》2014年第14期1687-1689,共3页Jiangsu Medical Journal

摘　　要：目的检测非小细胞肺癌(NSCLC)患者IL-13Rα2单核苷酸多态性(SNP)(rs17095919)位点的多态性,探讨其相关的临床意义。方法采用RT-PCR Taqman分析检测NSCLC患者(A组,96例)和健康体检者(B组,40例)SNP多态性。结果 A组患者C/C、C/T和T/T基因型频率分别为22.9%、51.0%和26.0%;B组分别为32.5%、30.0%和37.5%。A组C/T基因型分布高于B组[51.1%(49/96)vs.30.0%(12/40)](P<0.05);A组C/T基因型与淋巴结转移、临床病理分期密切相关(P<0.05),而与吸烟和肿瘤分化程度无明显关系(P>0.05)。结论 IL-13Rα2SNP C/T基因型与NSCLC的易感性密切相关,对NSCLC的早期诊断、临床分级以及预后评估等有一定价值。Objective To investigate the polymorphism of IL-13Rα2 single nucleotide polymorphism（SNP） （rs17095919） and its clinical significance in non-small cell lung cancer（NSCLC）. Methods With the standard RT-PCR Taqman assay,the genotypes of [L-13Rα2 SNP was detected in 96 patients with NSCLC（group A） and 40 healthy persons（group B）. Results The C/C, C/T, and T/T genotypes of IL13-Rα2 SNPs in group A accounted for 22.9 %, 51.0 %, and 26.0 %, respectively, which were 32. 5%,30.0%,and 37.5% in group B. The C/T genotype was higher in group A than that in group B[51.1%（49/96） vs. 30, 0%（12/40）]（P〈0. 05）. The C/T genotype in group A was closely related to lymphatic metastasis and clinical pathologic stage（P〈0. 05）, but not significantly related to smoking and histological grade（P〉0. 05）. Conclusion IL-13Rα2 SNP C/T genotype is closely related with the susceptibility of patients to NSCLC and has a certain value in making early diagnosis, clinically grading and evaluating the prognosis of NSCLC.

关 键 词：非小细胞肺癌 IL-13受体α2 单核苷酸多态性 

分 类 号：R734[医药卫生—肿瘤]