20-HETE调控血压及血糖的研究进展  

Progress of 20-HETE on blood pressure and glucose regulation

作　　者：赖光锐 赵彦艳[1,2] 

机构地区：[1]中国医科大学附属盛京医院临床遗传科,沈阳110004 [2]中国医科大学医学遗传学教研室,沈阳110004

出　　处：《国际遗传学杂志》2014年第4期178-182,共5页International Journal of Genetics

基　　金：国家自然科学基金（81270343）

摘　　要：细胞色素P450（CYP）4A和4F酶将花生四烯酸代谢生成二十羟基二十碳四烯酸（20-HETE），20-HETE一方面通过收缩外周血管起升高血压作用，另一方面，通过抑制水钠吸收起抗高血压作用。在高血压动物模型中发现20-HETE不仅仅与高血压密切相关，还发现20-HETE的变化伴随着血糖的异常，而后在糖尿病动物模型及人群中也证实了20-HETE的改变。该文就对20-HETE在血压、血糖调控方面作一综述。The cytochrome P450 4 A and 4 F family catalyze the metabolism of araehidonie acid to 20-hydroxyeicosatetraenoic acid （20-HETE）. 20-HETE has two contradictory effects in the develop- ment of hypertension. One is prohypertension resulting from constriction of the small arteries. The other is anti- hypertension caused by inhibition of sodium reabsorption. In the animal modes of hypertension, they suggested that 20-HETE is not only closely associated with hypertension, but also accompanies with blood glucose abnormalities. Furthermore, the abnormal 20-HETE level was also found in some diabetic animal models and human affected with diabetes. In this paper, 20-HETE on blood pressure and glucose regulation was reviewed.

关 键 词：二十羟基二十碳四烯酸 血压 血糖 

分 类 号：R544.1[医药卫生—心血管疾病] R-332[医药卫生—内科学]