MicroRNA和DNA甲基化在肺癌诊断中的研究进展  

Research progress of MicroRNA and DNA methylation in diagnosis of lung cancer

作　　者：周安燕[1] 吴秋歌[1] 王静[1] 

机构地区：[1]郑州大学第一附属医院呼吸与危重症医学科,450052

出　　处：《国际呼吸杂志》2014年第16期1241-1244,共4页International Journal of Respiration

摘　　要：小分子核糖核酸（MicroRNA）作为肺癌早期的一种新的生物标志物，为肿癌的诊断提供了一种新的方法。MicroRNA在肿瘤发生发展过程中发挥癌基因和抑癌基因的作用。MicroRNA与肺癌增殖、侵袭、治疗、预后和复发有着密切关系。DNA甲基化是目前最主要的一种表观遗传修饰形式，抑癌基因的高甲基化使DNA染色质构象发生改变导致转录失活，引起肿瘤发生。DNA甲基化和MicroRNA在功能上相互调控，对肺癌的发生、发展同样重要。As a new kind of early lung cancer biomarker, MicroRNA provides a new method for the diagnosis of lung cancer. MicroRNA plays the role of oncogene and tumor suppressor genes in the process of cancer development. MicroRNA is closely related to proliferation, invasion, treatment, prognosis, and recurrence of lung cancer. DNA methylation is one of the most major forms of epigenetic modifications, high methylation of tumor suppressor genes causes conformation changes of DNA chromatin leading to transcriptional inactivation,thus it arouses tumorigenesis. DNA methylation and MicroRNA regulate each other and play an equally importance in lung cancer development.

关 键 词：MICRORNA DNA甲基化 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]