血脂与大肠息肉的相关性研究  

Correlation between blood lipid and colorectal polys

作　　者：陆一新[1] 汤林波[1] 姜华[1] 邱允忠 张静燕[1] 刘庆晔[1] 

机构地区：[1]常州市武进中医医院,常州213161

出　　处：《新医学》2014年第8期533-535,共3页Journal of New Medicine

基　　金：常州市武进区科技项目(WS201232)

摘　　要：目的探讨血脂与大肠息肉的相关性。方法根据结肠镜检查及活组织病理学检查结果将129例被纳入研究的患者分为大肠息肉组(51例)和对照组(78例),记录两组研究对象的BMI、高血压病、糖尿病病史等;记录血脂检测结果,包括总胆固醇、甘油三酯、HDL-C、LDL-C、载脂蛋白A1(APOA1)、载脂蛋白B(APOB)、脂蛋白a,应用Logistic回归分析方法分析大肠息肉与各研究因素的相关性。结果高甘油三酯(OR=3.88)、男性(OR=3.11)、年龄≥50岁(OR=5.19)与大肠息肉呈正相关,高总胆固醇(OR=0.19)与大肠息肉成负相关(P均<0.05)。结论血脂异常与大肠息肉相关,可能有助于筛查大肠息肉。Objective To explore the correlation between blood lipid and colorectal polys. Methods One hundred and twenty-nine patients were divided into the colorectal polys and control groups according to the endoscopic findings and biopsy pathologic results. Multiple factors including body mass index （BMI）, his- tory of hypertension and diabetes were recorded. Serum total cholesterol, triglyceride, high density lipoprotein cholesterol （ HDL-C）, low density lipoprotein cholesterol （ LDL-C）, apolipoprotein A1 （ APOA1 ）, apolipoprotein B （APOB） and lipoprotein a （APOA） were measured in two groups. Logistic regression analysis was uti- lized to analyze the correlation between the incidence of colorectal polys and each factor. Results High triglyceride （ OR = 3.88 ）, male （ OR = 3.11 ） and age ≥50-year-old （ OR = 5. 19 ） were positively whereas high serum total cholesterol （ OR = 0. 19） was negatively correlated with the incidence of colorectal polys （ P 〈 0.05）. Conclusion Dyslipidemia is correlated with the incidence of colorectal polys, contributing to clinical screening of colorectal polys.

关 键 词：血脂 大肠息肉 甘油三酯 

分 类 号：R735.34[医药卫生—肿瘤]