小Y核型对男性不育影响的临床分析  

The Clinical analysis of the influence of bit Y chromosome abnormality on male fertile function

作　　者：陈亮[1] 付杰[1] 陈菲[1] 潘虹[1] 王玲[1] 鞠慧岩[1] 薛晴[1] 贺占举[1] 左文莉[1] 徐阳[1] 

机构地区：[1]北京大学第一医院生殖与遗传医疗中心,北京100034

出　　处：《中国性科学》2014年第8期74-76,共3页Chinese Journal of Human Sexuality

基　　金：2014年北京市自然科学基金资助项目(7142158);北京大学第一医院留学归国基金项目资助

摘　　要：目的:探讨单纯小Y染色体核型对男性生育障碍的影响及其临床意义。方法:研究对象分为A组(男性不育)及B组(配偶既往不良妊娠史或羊水穿刺示胎儿染色体异常等),比较不同组别间小Y核型的检出率并分析其临床效应。结果:共检出30例小Y核型。其中A组12例,B组18例。两组间小Y核型的检出率没有显著差异(P=0.971)。小Y核型的临床效应为:无精症、少精症、配偶胚胎停育、自然流产等不良妊娠结局。结论:小Y核型可能具备某些潜在的临床效应,可能会对男性生精过程及配偶的不良妊娠结局产生影响,需要在分子生物学及功能基因组学层面继续深入验证。To investigate the effects of bit Y chromosome configuration on male fertility and to evaluate the relevant clinical significance.Methods：The relevant cases were divided into two groups,where A group included male infertile cases while B group included cases whose wife had adverse pregnancy history or the ab-normal amniotic fluid punctures.Cytogenetics of patients was examined by culturing peripheral-blood lymphocyte and G-banding technology,and karyotyping analysis technique was used to study the bit Y chromosome in two dif-ferent groups.Results：Among the 2139 cases,30 cases were found with abnormal karyotype of bit Y chromo-some.,including 12 ones in group A and 18 ones in group B,with no significant difference （P=0.971）.The main clinical effects of bit Y were azoospermia,oligozoospermia,miscarriage,embryonic diapause and fetal anomalies,et al.Conclusion：The bit Y chromosomal abnormality may have some potential clinical effects which may affect the spermatogenesis and adverse pregnancy.Therefore,a detailed mechanism study needs to be further investigated.

关 键 词：染色体核型 小Y染色体 男性不育症 

分 类 号：R698.2[医药卫生—泌尿科学]