37384例妇女宫颈人乳头状瘤病毒感染状况研究  

Study on cervical HPV infection status in 37384 women

作　　者：魏睿[1] 张振中[1] 程腾[1] 赵海月[1] 李飞[1] 奚玲[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤生物医学中心,湖北武汉430030

出　　处：《中国妇幼保健》2014年第24期3885-3888,共4页Maternal and Child Health Care of China

基　　金：国家自然科学基金面上项目〔81172468〕

摘　　要：目的：了解华中地区妇科门诊患者宫颈乳头状瘤病毒（HPV）感染状况,分析HPV感染状况与年份、年龄及季节的关系,为筛查HPV高危人群及预防提供科学依据。方法：对2006年3月~2013年10月近8年时间内来该院妇科门诊就诊的37 384例患者进行登记,收集其阴道、宫颈分泌物,采用第二代杂交捕获（hybrid capture 2,HC2）技术检测患者13种高危型人乳头状瘤病毒（HR-HPV）感染情况。结果：12006~2013年HPV筛查的总人数逐年增加,但HPV检出阳性的总人数并没有明显变化,HPV阳性检出率呈下降趋势。2〈20岁、21~30岁、31~40岁、41~50岁、51~60岁、61~70岁和〉70岁不同年龄段患者的HR-HPV感染率分别是26.35%、16.53%、18.68%、17.21%、16.09%、14.47%、13.21%,各组间比较差异有统计学意义（χ2=40.47,P〈0.05）,HPV检出率呈双峰状20岁以下和31~40岁,其中以20岁以下年龄段感染检出率最高,61岁以上相对较低。平均感染率17.13%。3在春季和秋季HPV感染率较其他季节高。结论：华中地区HR-HPV感染率与其他地区相比处于中等水平,HPV感染率和年龄、季节有一定相关性,宫颈癌高发年龄在40~50岁,HPV感染高危人群30~40岁的妇女应该是重点筛查对象,特别是在春秋两季。该结果可用于指导HPV高危人群的筛查,有利于预测病变转归,指导临床治疗和随访。Objective： To understand the infection status of cervical human papillomavirus （HPV） in gynecological outpatient department of Central China, analyze the relationship between HPV infection status and a particular year, age, season, provide a scientific basis for screening and preventing HPV infection in high risk population. Methods： A total of 37 384 patients from gynecological outpatient department in the hospital from March 2006 to October 2013 were registered; vaginal and cervical secretions were collected; HC2 was used to detect infection status of 13 high risk HPV subtypes. Results： From 2006 to 2013, the total number of women receiving HPV screening increased year by year, but the total number of women with positive HPV didnt change obviously, the positive detection rate of HPV showed a decreasing trend. The infection rates of high risk HPV in patients in 〈20 -yearold group, 21 -30 -yearold group, 31 -40 -yearold group, 41 - 50 - year - old group, 51 - 60 - year - old group, 61 - 70 - year - old group and 〉 70 - year - old group were 26. 35% , 16. 53%, 18. 68%, 17. 21%, 16. 09%, 14.47% and 13.21%, respectively, there was statistically significant difference （X2 =40. 47, P 〈 0. 05 ）, the peak of HPV infection rate appeared in 〈 20 - year - old group and 31 - 40 - year - old group, the detection rate of HPV in 〈 20 - year - old group was the highest, and the detection rate of HPV in women more than 61 years old was relatively low ; the mean infec- tion rate of HPV was 17.13% ; the infection rates of HPV in spring and autumn were higher than those in summer and winter. Conclusion： High risk HPV infection rate in Central China is in intermediate level compared with the other areas. HPV infection rate is related to age and season. The incidence rate of cervical cancer in women aged 40 - 50 years old is high, the women aged 30 - 40 years old are high risk population of HPV, which are also key screening objects, especially in spring and autumn; the conclusion can direct HPV screening in

关 键 词：人乳头瘤病毒 群集筛查 宫颈癌 第二代杂交捕获法 流行病学调查 

分 类 号：R737.31[医药卫生—肿瘤]