N2期肺癌术后早期复发与CXC趋化因子受体4表达的关系  

Relationship between CXC chemokine receptor-4 expression and postoperative early recurrence in patients with N2 lung cancer

作　　者：陈钢[1] 刘相燕[1] 王洲 刘曦[2] 

机构地区：[1]山东大学附属省立医院胸外科,济南250021 [2]山东大学医学院

出　　处：《中华实验外科杂志》2014年第8期1629-1631,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金青年科学基金资助项目（81302021）;山东省自然科学基金资助项目（Y2007C106）

摘　　要：目的 探讨CXC趋化因子受体4（CXCR4）的表达与N2期肺癌术后早期复发的关系.方法 采用逆转录-聚合酶链反应（RT-PCR）方法检测84例手术治疗的N2期非小细胞肺癌患者的癌组织中CXCR4mRNA的表达,应用x2检验比较CXCR4表达的差异.随访患者并分析N2期肺癌术后早期复发模式.应用Logistic回归分析判定N2期肺癌术后早期复发的独立相关因素.结果 CXCR4mRNA在60例（71.4％）肺癌组织中表达,与年龄、性别、肿瘤类型、分化程度、T分期均无相关（P＞0.05）.术后1年内39例（46.4％）患者肿瘤复发,以转移性复发为主（74.4％）.CXCR4表达阳性患者复发率明显高于阴性患者（P＜0.05）.术后1年总体生存率为65.48％,CXCR4表达阳性患者无复发生存期显著低于阴性患者（P＜0.05）.Logistic回归分析结果显示,癌组织中CXCR4表达、未行术后辅助治疗是N2期肺癌术后早期复发的独立相关因素.结论 CXCR4在N2期肺癌组织中高表达,与术后早期复发密切相关;N2期肺癌患者术后早期复发模式主要为转移性复发.Objective To investigate the relationship between CXC chemokine receptor-4 （CXCR4） expression and postoperative early recurrence in patients with N2 lung cancer.Methods The cancer tissues from 84 patients with N2 lung cancer were examined by reverse transcription-polymerase chain reaction （RT-PCR） for detection of the CXCR4 mRNA expression.The difference was compared by x2 test.All patients were evaluated within 1 year after surgery to monitor tumor recurrence.Logistic regression analysis was performed to determine the risk factors of early recurrence.Results CXCR4 expression was observed in 60 cases of （71.4％） lung cancer.Early recurrence occurred in 39 patients （46.4％）,and the main pattern was hematogenous.The recurrence rate in patients positive for CXCR4 expression was significantly higher than in those negative for the CXCR4 expression （P ＜ 0.05）.The overall 1-year survival rate was 65.48％,and recurrence-free survival in patients positive for the CXCR4 expression was significantly shorter than that in those negative for the CXCR4 expression （P ＜ 0.05）.Logistic regression analysis revealed that positive CXCR4 expression [odds ratio （OR） =5.048,P ＜ 0.01] and no postoperative adjuvant therapy （OR =3.806,P ＜ 0.05） were independent risk factors of postoperative early recurrence.Conclusion CXCR4 expression was high in N2 lung cancer,with significant correlation to postoperative early recurrence.About one half of the patients would develop recurrence within 1 year after surgery,with mainly hematogenous metastasis.

关 键 词：肺癌 肿瘤复发 CXC趋化因子受体4 

分 类 号：R734.2[医药卫生—肿瘤]