涎腺腺泡细胞癌5例报道并文献复习  

Acinic cell carcinoma: five cases report and review of literates

作　　者：王志强[1] 胡利兵 黄述斌[1] 李松梅[1] 

机构地区：[1]池州市人民医院病理科,安徽池州247000 [2]池州市人民医院口腔科

出　　处：《中国肿瘤外科杂志》2014年第4期230-232,共3页Chinese Journal of Surgical Oncology

摘　　要：目的 探讨涎腺腺泡细胞癌的临床病理学特征和预后相关因素。方法 回顾性分析5例涎腺腺泡细胞癌的临床资料、组织学形态和免疫表型,并复习相关文献。结果 男1例,女4例。肿瘤位于口腔牙龈1例,腮腺4例。临床表现为生长缓慢无痛性肿块4例,另1例肿瘤近期生长迅速,偶有疼痛。镜下观察：组织学形态4例呈乳头囊状型,肿瘤细胞形态温和;1例实性伴微囊型肿瘤浸润性生长伴点灶状坏死,肿瘤细胞异形明显,呈高级别转化形态。免疫组化染色示CK阳性,P63、SMA阴性;Ki-67阳性指数4例〈5%,1例高级别患者为30%。4例随访13~78个月,未见肿瘤复发和转移;1例高级别患者术后10个月死亡。结论 腺泡细胞癌好发于女性腮腺,通常为低度恶性,而高级别转化腺泡细胞癌预后差,其临床综合治疗尚须进一步探讨。Objective To investigate the clinico-pathological characteristics and prognostic factors of acinic cell carcinoma（AciCC）. Methods Five cases diagnosed AciCC were investigated with clinical date, histology and immunohistochemistry. The literatures were reviewed. Results Among 5 cases, 4 cases were females and 1 case was male. The lesions were involved in parotid 4 cases, and oral gingival 1 case. 4 patients showed slow-growing painless mass and one patient complained the tumor rapid grow in recent, occasional pain. Microscopically, 4 cases represented papillary cystic type and the neoplastic cells were moderate. Necrosis was present in one case of high-grade AeiCC. The neoplastic cells were positive for CK but negative for P63 and SMA. The Ki- 67 index was low （ 〈5% ） in 4 cases, while it was high （30%） in the high-grade compoent. 4 cases were followed up for 13-78 months, and recurrence and metastasis were not found. The patient of high-grade AciCC died 10 months after operated. Conclusions AeiCC often occurs predominantly in parotid of female. Most of AciCCs are low-grade. However, the patients of high-grade AciCC need further explore about comprehensive clinical treatment and closely followed up.

关 键 词：腺泡细胞癌 高级别转化 病理学 免疫组织化学 预后 

分 类 号：R739.87[医药卫生—肿瘤]