黔产五香血藤化学成分的研究(Ⅱ)  

Chemical Constituents of Kadsura longipedunculata( Ⅱ)

作　　者：江雪清[1] 干正洋[1] 晏晨[2] 吕阳阳[1] 宋万琚[1] 

机构地区：[1]贵州师范学院化学与生命科学学院,贵阳550018 [2]贵州省中国科学院天然产物化学重点实验室,贵阳550002

出　　处：《中国实验方剂学杂志》2014年第16期67-70,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：贵州省自然科学基金项目(黔科合J字[2011]2346号);贵州省应用化学特色重点学科项目(黔教科研发[2012]442号)

摘　　要：目的：研究黔产五香血藤的化学组成,探究其活性成分.方法：采用硅胶柱色谱、大孔树脂柱色谱、分子筛色谱、重结晶、高效液相色谱纯化等方法,从五香血藤乙醇提取物的石油醚和乙酸乙酯部分分离纯化化合物,并根据其理化性质、核磁共振氢谱、碳谱、及质谱等波谱数据鉴定结构.结果：分离并鉴定了8个化合物,分别为五内酯E甲酯（1）,北五味子酸（2）,sorghumol（3）,黑色五味子单体苷（4）,lancilactone C（5）,南五味子宁（6）,β-谷甾醇（7）,（＋）-安五脂素（8）.结论：化合物2～5为首次从该植物中分离得到,其中,1,2,3,5为三萜类化合物,4,6,8为木脂素类化合物.Objective：This study was aimed to investigate the chemical constituent of Kadsura longipeduculata collected from Guizhou province,and to explore the active ingredients in this herb.Method：Methods including silica gel column chromatography,macroporous resin column chromatography,molecular sieve chromatography,recrystallization and HPLC preparation were used.And the constituents were separated and purified from the petroleum ether and ethyl acetate fractions of ethanol extract of K.longipeduculata.According to their physical and chemical properties,coupled with the data of 1H-NMR,13C-NMR and EIS-MS,the structures were elucidated.Result：Eight compounds were isolated and identified as tubiferolide methyl ester （1）,schizandronic acid （2）,sorghumol （3）,schizandriside （4）,lancilactone C （5）,kadsurarin （6）,β-sitosterol （7）,（＋）-anwulignan （8）.Conclusion：Compounds 2-5 are isolated from the plant for the first time.1,2,3,5 are triterpene compounds,and 4,6,8 are lignans compounds.

关 键 词：五香血藤 化学成分 木脂素 三萜 

分 类 号：R284.1[医药卫生—中药学]