无配体铜催化氮杂环化合物的N-芳基化反应  

Ligand-Free Copper-catalyzed N-Arylation of Nitrogen Heterocyclic Compounds

作　　者：史雪松[1] 张敬先[1] 韩世清[1] 

机构地区：[1]南京工业大学生物与制药工程学院,江苏南京211816

出　　处：《化学世界》2014年第8期488-492,共5页Chemical World

摘　　要：为建立经济,高效,环保的含氮杂环化合物的N-芳基化反应体系,考察了不同取代的芳烃卤化物与氮杂环芳香化合物在无配体下使用廉价易得的铜盐为催化剂,1,4-二氧六环为溶剂的N-芳基化反应。实验结果表明,该反应体系在以廉价的氧化亚铜为催化剂,回流状态下含氮杂环化合物与卤代芳烃顺利反应生成C-N偶联产物,得到优良的产率。Using simple copper salt as catalyst and 1,4-dioxane as solvent, an economic, efficient and environmental friendly method for N-arylation of nitrogen-containing heterocycles with aryl and heteroaryl halides was developed. The reaction between nitrogen heterocycles and aryl halides with different substituents was explored. The results showed that N-arylation of nitrogen-containing heterocycles with aryl and heteroaryl halides generated C-N coupling products smoothly under relux conditions when using Cu20 as catalyst. All the products were synthesized with good to excellent yield.

关 键 词：铜 氮杂环化合物 N-芳基化 

分 类 号：O625.6[理学—有机化学]