氢元素存在形式与钛表面生物学活性体外矿化能力研究  

An in vitro mineralization study of hydrogen existence form and surface bioactivity of titanium

作　　者：林曦[1] 周磊[1] 丁祥龙[1] 贾芳[1] 刘伟珍[1] 丁婧文[1] 

机构地区：[1]南方医科大学附属口腔医院.广东省口腔医院,广州510280

出　　处：《实用口腔医学杂志》2014年第4期451-455,共5页Journal of Practical Stomatology

基　　金：国家自然科学基金(编号:81170998)

摘　　要：目的:研究氢元素存在形式与钛表面生物学活性相关关系。方法:用硫酸和盐酸对喷砂钛表面进行酸蚀(酸蚀组,SLA,n=3),并对其进行加热处理(450℃)(酸蚀加热组,SLA+HT,n=3),分析其表面形貌、粗糙度、亲水性、表面晶体结构差异。将酸蚀组及加热组钛片浸泡于标准模拟体液中3 d,比较其体外矿化能力。结果:酸蚀后钛表面形成氢化钛,加热至450℃时钛表面形貌及粗糙度没有明显改变,氢化钛分解。模拟体液实验结果示喷砂酸蚀组于第3天无明显羟基磷灰石沉积,加热组钛表面有大量羟基磷灰石沉积。结论:喷砂酸蚀后氢与钛形成的氢化钛对钛表面生物活性无明显促进作用;加热后氢化钛分解,矿化能力增加。Objective：To investigate the relationship between surface hydrogen form and the bioactivity of titanium.Methods：Sandblast titanium was etched with the combination of sulfuric and hydrochloric acids（SLA group,n=3 ）.Then etched titanium was heat at 450 ℃in air（SLA＋HT group,n=3）.Surface topography,roughness,hydrophility,surface chemical texture were observed. Finally,the titanium samples were soaked in body simulate fluid for 3 days,the mineral deposition properties were observed by X-ray diffraction.Results：Titanium hydride was formed on the titanium surface after etching.After heat treatment,surface texture and roughness were not changed,titanium hydride decomposed and hydrophility increased.More hydroxyapatite was found on the surface of the samples treated by SLA＋HT and followed by SBF.Conclusion：Titanium hydride can not improve the bioactivity of titanium, heat treatment may increase the mineralization.

关 键 词：钛 种植体 氢化钛 羟基 亲水性 模拟体液(SBF) 

分 类 号：R783.1[医药卫生—口腔医学]