西吡氯铵含片对牙菌斑抑制效果的临床试验研究  

Inhibitory effects of cetylpyridinium chloride buccal tablets on dental plaque

作　　者：谭媛元[1] 张剑英[1] 张冠荣[2] 付云[1] 

机构地区：[1]中山大学光华口腔医学院.附属口腔医院牙周科.广东省口腔重点实验室,广州510055 [2]广东省人民医院.广东省医学科学院健康管理(体检)中心

出　　处：《实用口腔医学杂志》2014年第4期538-542,共5页Journal of Practical Stomatology

摘　　要：目的:探讨西吡氯铵含片(CCBT)对控制牙面菌斑堆积和牙龈炎症的效果。方法:采用随机单盲对照试验,纳入60名患有慢性龈炎、轻、中度慢性牙周炎患者。对全部患者卫生宣教后随机分为3组,对照组不用药,试验组使用CCBT,阳性对照组使用复方氯己定(CHX)含漱液。治疗前、治疗后第2周记录Quigley-Hein菌斑指数(PI)及出血指数(BI);酶联免疫吸附试验法检测龈沟液中肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)表达水平的改变。结果:治疗前3组间比较PI、BI、龈沟液TNF-α和IL-1β含量均无显著差异(P>0.05)。治疗后CCBT组和CHX组PI和BI均明显下降(P<0.01),2组的下降值均无显著差异(P>0.05);龈沟液中TNF-α含量均下降(P<0.05)。对照组治疗后PI下降(P<0.05),其他指标无变化(P>0.05)。结论:西吡氯铵含片有抑制牙菌斑堆积作用,可改善牙龈炎症,降低龈沟液中TNF-α表达。Objective：To investigate the effects of cetylpyridinium chloride buccal tablets（CCBT）on dental plaque control.Methods：60 patients with gingivitis,mild or moderate,or chronic periodontitis were divided into control group（without drug treatment）, CCBT group （treated with CCBT）and CHX group （treated with compound chlorhexidine gargle）according to the randomized con-trolled single-blind principle.Quigley-Hein plaque index （PI）and bleeding index （BI）of the subjects were recorded,tumor necro-sis factor （TNF-α）and interleukin （IL-1β）in gingival crevicular fluid （GCF）were measured by ELISA before and after 2 weeks＇trial.Results：After 2-week treatment,PI and BI in CCBT and CHX groups decreased（P〈0.01）;TNF-αin GCF decreased（P〈0.05）,IL-1βcontent was not changed.The changes of PI and BI were not significant between CCBT and CHX groups（P〉0.05）. In control group PI was decreased（P〈0.05）,other measurements were not changed（P〉005）.Conclusion：CCBT is effective in inhibiting plaque accumulation and decreasing GCF TNF-αlevel.

关 键 词：西吡氯铵含片 菌斑指数 出血指数 肿瘤坏死因子Α 白细胞介素1Β 

分 类 号：R781.4[医药卫生—口腔医学]