河南省某地区人群肥胖易感性与神经肽Y及其受体基因多态性的关系  

Relationships between obese population-susceptibility and gene polymorphisms of neuropeptide Y and its receptor in a region of Henan Province,China

作　　者：刘卫刚[1,2] 陆云[3] 李琳琳[4] 李筠青[1] 盛学文[1] 尹磊 张功员[4] 赵景志 

机构地区：[1]河北工程大学附属医院病案统计室,河北邯郸056002 [2]河南省军区直属医院办公室,河南郑州450003 [3]河北工程大学附属医院肾内科,河北邯郸056002 [4]郑州大学公共卫生学院卫生统计学教研室,河南郑州450001

出　　处：《山东大学学报（医学版）》2014年第8期98-101,107,共5页Journal of Shandong University:Health Sciences

基　　金：河南省医学科技攻关项目(201004042)

摘　　要：目的探讨河南省某地区人群肥胖易感性与神经肽Y及其受体基因多态性的关系。方法随机整群抽取510例河南省某地区18岁以上常住居民,进行不同程度BMI与基因易感性分析。结果 rs2880412、rs2880416 2个位点基因分布差异有统计学意义(P<0.05);基因突变率与基因型分布呈整体升高趋势(P<0.05);3个位点基因型的不同与肥胖发生之间存在关联(P<0.05),CA、GA、GC 3种单体型在肥胖组和非肥胖组中的分布差异有统计学意义(P<0.05);以CA作为对照单体型,GA、GC单体型与肥胖的易感性有关联(P<0.05)。结论rs2880412、rs2880416位点的基因多态性与肥胖易感性有统计学关联,并且2个位点对应的等位基因C、C是肥胖发生的危险因素,单体型分析表明3个位点存在交互作用。Objective To investigate the relationships between obese population-susceptibility and gene polymorphisms of neuropeptide Y and its receptors in a region of Henan Province,China. Methods We selected 510 inhabitants aged over 18 in a region of Henan Province by the method of random cluster sampling,and analyzed the relationships of obesity degree with genetic susceptibilities. Results The genic distributions of rs2880412 and rs2880416 had statistical differences（ P〈0. 05）. The rates of genic mutation and the distributions of genotypes showed the overall increasing trend（ P〈0. 05）. Three sites of different genotypes had relevance to the occurrence of disease. The distributions in three kinds of haplotypes,including CA,GA and GC,had statistical differences between obese and non-obese groups（ P〈0.05）. When haplotype CA was as a control,haplotypes GA and GC were relevant to obese susceptibility（ P〈0. 05）. Conclusion Gene polymorphisms of rs2880412 and rs2880416 sites are statistically relevant to obese susceptibilities. The corresponding allele C and C of them are risk factors of obesity. Haplotype-analysis showed that there are interactions in the three sites.

关 键 词：基因多态性 肥胖 易感性 单体型 

分 类 号：R181.2[医药卫生—流行病学]