Non-apoptotic role of caspase-3 in synapse ref inement  

作　　者：Jin-Yuan Wang Zhen-Ge Luo 

机构地区：[1]Institute of Neuroscience,State Key Laboratory of Neuroscience,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences

出　　处：《Neuroscience Bulletin》2014年第4期667-670,共4页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation (31330032,31321091,and 61327902);he National Basic Research Development Program of China (2014CB910203)

摘　　要：Caspases, a family of cysteine proteases, mediate programmed cell death during early neural development and neurodegeneration, as well as following neurotoxic insults. Notably, accumulating lines of evidence have shown non-apoptotic roles of caspases in the structural and functional plasticity of neuronal circuits under physiological conditions, such as growth-cone dynamics and axonal/dendritic pruning, as well as neuronal excitability and plasticity. Here, we summarize recent progress on the roles of caspases in synaptic refinement.Caspases, a family of cysteine proteases, mediate programmed cell death during early neural development and neurodegeneration, as well as following neurotoxic insults. Notably, accumulating lines of evidence have shown non-apoptotic roles of caspases in the structural and functional plasticity of neuronal circuits under physiological conditions, such as growth-cone dynamics and axonal/dendritic pruning, as well as neuronal excitability and plasticity. Here, we summarize recent progress on the roles of caspases in synaptic refinement.

关 键 词：CASPASES neuronal plasticity synaptic refinement 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]