Supported by the Scientific Research Project of Shaanxi Provincial Department of Health:the Protective Role of Celastrol and its Active Mechanisms in Neuroblastoma Treatment (2020A1515003129)。
OBJECTIVE: To investigate the in-depth pharmacological mechanisms of celastrol in children neuroblastoma treatment. METHODS: In the current study, we examined the effects of celastrol on children neuroblastoma cells v...
supported by the Science and Technology Support Program of Guizhou Province([2021]GenaralA10).
Cytosolic nucleic acid sensors are critical for sensing nucleic acids and initiating innate immunity during microbial infections and/or cell death.Over the last decade,several key studies have characterized the conser...
Supported by Nanjing Medical Science and technique Development Foundation (No.QRX17194)。
OBJECTIVE: To investigate the efficacy of celastrol treatment of hepatocellular carcinoma(HCC) cells in vitro and in vivo and to propose a mechanism of action.METHODS: A human Hep G2 liver cancer cell line and a xenog...