The crosstalk between the caspase family and the cGAS-STING signaling pathway  

作　　者：Yongai Xiong Yan-Dong Tang Chunfu Zheng 

机构地区：[1]Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy,Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education,Zunyi Medical University,Zunyi,China [2]Department of Immunology,School of Basic Medical Sciences,Fujian Medical University,Fuzhou,China [3]State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences,Harbin,China [4]Department of Microbiology,Immunology and Infectious Diseases,University of Calgary,Calgary,Alberta,Canada

出　　处：《Journal of Molecular Cell Biology》2021年第10期739-747,共9页分子细胞生物学报（英文版）

基　　金：supported by the Science and Technology Support Program of Guizhou Province([2021]GenaralA10).

摘　　要：Cytosolic nucleic acid sensors are critical for sensing nucleic acids and initiating innate immunity during microbial infections and/or cell death.Over the last decade,several key studies have characterized the conserved mechanism of cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)and the downstream signaling adaptor stimulator of interferon genes(STING)initiating the innate immune signaling pathways.Aside from its primary involvement in microbial infections and inflammatory diseases,there is growing interest in the alternate roles of cGAS-STING-mediated signaling.Caspase family members are powerful functional proteins that respond to cellular stress,including cell death signals,inflammation,and innate immunity.Recent studies have uncovered how the caspase family cooperates with the cGAS-STING signaling pathway.Most caspase family members negatively regulate the cGAS-STING signaling pathway.In turn,some caspase family members can also be modulated by cGAS-STING.This review gives a detailed account of the interplay between the caspase family and the cGAS-STING signaling pathway,which will shed light on developing novel therapeutics targeting the caspase family and cGAS-STING signaling in antiviral innate immunity,cancer,inflammatory,and autoimmunity.

关 键 词：cGAS-STING CASPASES innate immunity signaling pathway 

分 类 号：Q55[生物学—生物化学]