人类癌症中长链非编码RNA与miRNA相互作用的研究进展  

Research progress of the interactions between long non-coding RNAs and miRNAs in human cancer

作　　者：尹凌帝 孙倩[1] 孙明[2] 德伟[2] 

机构地区：[1]南京医科大学第一临床医学院,南京210029 [2]南京医科大学生物化学与分子生物学系,210029

出　　处：《临床肿瘤学杂志》2014年第7期662-666,共5页Chinese Clinical Oncology

基　　金：国家自然科学基金资助项目(81070620)

摘　　要：人类基因组中大部分为非编码区,转录产生非编码RNA(ncRNA)。这些ncRNA可以在表观遗传学水平及转录后水平调控癌基因和抑癌基因的表达,影响肿瘤的发生和发展,是肿瘤诊断、治疗及预后判断的潜在靶标。微小RNA(miRNA)和长链非编码RNA(lncRNA)是ncRNA的两个重要分类。其中,lncRNA通过多种机制在不同水平进行基因表达调控,发挥其生物学功能,这些机制包括基因印迹、染色质重塑、细胞周期调控、选择性剪接、mRNA降解和翻译调控等。近年来,miRNA和lncRNA在癌症发生发展中相互作用的分子机制引起了人们的注意。本文主要就这两者在癌症发生发展过程中的相互作用机制及研究方法进行综述。Most of the genome are non-coding regions, from which the non-coding RNAs（ ncRNA） are transcribed. These ncRNAs may play vital roles in tumorigenesis by regulating oncogene and tumor suppressor gene at either epigenetic level or post-tran-scriptional level, and act as potential targets for tumor diagnosis, prognosis and therapy. MicroRNA（miRNA） and long non-coding RNA（ lncRNA） are two important subspecies of ncRNA. LncRNAs play biological roles through a variety of mechanisms, including ge-netic imprinting, chromatin remodeling, cell cycle control, splicing regulation, mRNA decay and translational regulation. Recently, the interaction between miRNA and lncRNA in the development and progression of cancer has drawn the attention of many researchers. This review focuses on the interaction between these two RNAs and its studying methods.

关 键 词：MIRNA lncRNA 癌症 

分 类 号：R730.2[医药卫生—肿瘤]