DNA甲基化在肝脏疾病发生与发展中的作用及其机制的研究进展  

Role and mechanisms of DNA methylation in liver diseases

作　　者：孔德松[1] 张峰[2,3] 邱萍[2] 郑仕中[2,3] 

机构地区：[1]南京中医药大学第三附属医院,江苏省南京市210001 [2]南京中医药大学药学院,江苏省南京市210023 [3]江苏省中药药效与安全性评价重点实验室,江苏省南京市210023

出　　处：《世界华人消化杂志》2014年第21期3041-3047,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;Nos.81270514;30873424;教育部博士点基金资助项目;No.20103237110010;江苏省自然科学基金资助项目;No.BK2008456;江苏省六大人才基金资助项目;No.2009-B-010;江苏省针灸学重点实验室开放课题基金资助项目;No.KJA200801;江苏高校优势学科建设工程基金资助项目;No.ysxk-2010;南京中医药大学中药学一级学科开放课题基金资助项目;No.2011ZYX4-008;十一五科技支撑计划基金资助项目;No.2008BAI51B02~~

摘　　要：DNA甲基化通过调节基因转录、印记、X染色体灭活和防御外源性遗传物质入侵等,在细胞分化、胚胎发育、环境适应和疾病发生发展上发挥重要作用,是当前表观遗传学研究的热点领域之一.越来越多的研究证实DNA甲基化在肝脏疾病的发生与发展过程中扮演着重要角色.DNA甲基化修饰通过调控肝脏内细胞脂质代谢、炎症反应、细胞增殖活化等基因与蛋白的表达,进而影响肝脏疾病的发展进程.本文详细阐述与分析了DNA甲基化在酒精性肝病、非酒精性脂肪肝、肝纤维化、病毒性肝炎及肝细胞癌中的具体作用机制及近年来的研究进展,以期能为肝病的治疗与药物的开发提供一定的理论支持.DNA methylation plays an important role in disease development, cell differentiation, embryonic development, and environmental adaptation by regulating gene transcription, gene imprinting and X chromosome inactivation and defending from invasion of exogenous genetic material. DNA methylation is a hot topic in the study of epigenetics. Numerous studies have demonstrated that DNA methylation plays an impor- tant role in the occurrence and development of liver diseases, and it influences the process of liver diseases through regulation of the activation and expression of genes related to lipid metabolism, inflammation, and cell proliferation in liver cells. In this review, we will review the recent progress in understanding the role and mechanisms of DNA methylation in alcoholic liver disease, nonalcoholic fatty liver disease, viral hepatitis, liver fibrosis and hepatocellular carcinoma, with an aim to provide a theoretical basis for the treatment of liver diseases and drug development.

关 键 词：DNA甲基化 酒精性肝病 非酒精性脂肪 肝 肝纤维化 病毒性肝炎 肝细胞癌 

分 类 号：R575[医药卫生—消化系统]