Wnt信号通路调控肝星状细胞活化及增殖在肝纤维化治疗中的研究进展  

Regulation of activation and proliferation of hepatic stellate cells through the Wnt signaling pathway: Implications for treatment of liver fibrosis

作　　者：马志刚[1] 陈兰[1] 詹灵凌[2] 吕小平[1] 

机构地区：[1]广西医科大学第一附属医院消化内科,广西壮族自治区南宁市530021 [2]广西医科大学第一附属医院临床医学实验部,广西壮族自治区南宁市530021

出　　处：《世界华人消化杂志》2014年第21期3048-3055,共8页World Chinese Journal of Digestology

基　　金：广西自然科学基金资助项目;No.2012GXNSFAA053143;广西科学研究与技术开发计划基金资助项目;No.桂科攻1355005-3-2~~

摘　　要：肝纤维化是一种发生于肝脏慢性损伤后的可逆性病理改变,他的发生与肝星状细胞(hepatic stellate cell,HSC)的激活、增殖密切相关.研究发现,Wnt信号通路参与HSC的激活过程,并进而影响肝纤维化的发生、发展.因此,Wnt信号通路和HSC被认为是治疗肝纤维化的有效靶点.近年来,国内外学者对二者的调控进行了大量研究,试图寻找出抗纤维化的有效途径.大量研究表明,通过Wnt信号通路调控HSC,能够对肝纤维化起到一定的治疗作用.本文从Wnt信号通路、HSC及肝纤维化三者的内在联系出发,对在肝纤维化治疗研究中,以Wnt信号通路为主要调控途径作用于HSC的最新研究作一综述.Liver fibrosis, a reversible pathological condition occurring after chronic liver injury, is closely associated with the activation and proliferation of hepatic stellate cells （HSCs）. Several studies have demonstrated that the Wnt signaling pathway is involved in the activation of HSCs, and then contributes to the occurrence and development of liver fibrosis. Thus, the Writ signaling pathway and HSCs are considered to be the valid targets for the treatment of liver fibrosis. In recent years, domestic and international scholars have carried on many studies on the regulation of the Wnt signaling pathway and HSCs, try- ing to find out effective antifibrotic therapies. A large number of studies have shown that regu- lating HSCs can play a positive role in the treatment of liver fibrosis through the Wnt signaling pathway. On the basis of the relationship among the Wnt signaling pathway, HSCs and liver fibrosis, this review mainly summarizes the latest progress in the study of strategies for regulating HSCs through the Wnt signaling pathway and discusses the implications for the treatment of liver fibrosis.

关 键 词：肝星状细胞 WNT信号通路 调控 肝纤维化 

分 类 号：R575.2[医药卫生—消化系统]