胃癌中RhoGDI2、CIAPIN1的原位表达及其相关性  

Expression of RhoGDI2 and CIAPIN1 in gastric carcinoma

作　　者：石干[1] 廖家智[2] 何星星[2] 孙圣斌[1] 黄曼玲[1] 杨静[1] 吴杰[1] 

机构地区：[1]华中科技大学同济医学院附属武汉市中心医院消化内科,湖北省武汉市430014 [2]华中科技大学同济医学院附属同济医院肝病研究所,湖北省武汉市430030

出　　处：《世界华人消化杂志》2014年第21期3106-3112,共7页World Chinese Journal of Digestology

基　　金：国家青年自然科学基金资助项目;No.81101824~~

摘　　要：目的:观察RhoGTP酶解离抑制蛋白2(RhoGTPase dissociation inhibitor 2,RhoGDI2)、细胞因子诱导的凋亡抑制因子1(cytokineinduced apoptosis inhibitor 1,CIAPIN1)在胃癌患者组织中的表达状况,并评价其与胃癌临床病理特征的相关性,分析两者表达相关性.方法:采用免疫组织化学技术检测94例胃癌组织中RhoGDI2、CIAPIN1的表达状况,并分析两者表达相关性.结果:胃癌组织中RhoGDI2和CIAPIN1蛋白表达阳性率分别为67.02%、77.66%;RhoGDI2和CIAPIN1在胃癌中的蛋白表达与胃癌分化程度、肿瘤浸润深度、淋巴结转移个数、有无远处转移和TNM分期显著相关;RhoGDI2与CIAPIN1的表达正相关.结论:胃癌组织RhoGDI2、CIAPIN1的蛋白表达水平密切相关.CIAPIN1极可能受到RhoGDI2的调控,为RhoGDI2在胃癌浸润转移过程中的下游靶点基因,两者很可能共同参与调节胃癌的侵袭转移过程.AIM： To detect the expression of RhoGTPase dis- sociation inhibitor 2 （RhoGDI2） and cytokine-in- duced apoptosis inhibitor I （CIAPIN1） in gastric cancer and to analyze their clinical significance. METHODS： Immunohistochemistry was used to detect the expression of RhoGDI2 and CIAPIN1 in 94 gastric cancer specimens. RESULTS： The positive rates of RhoGDI2 and CIAPIN1 in gastric cancer were 67.02%and 77.66%, respectively. The expression of RhoGDI2 and CIAPIN1 was related to tumor differentiation, depth of invasion, lymph node metastasis, distant metastasis and TNM stage in gastric cancer. There was a positive correla- tion between the expression of RhoGDI2 and that of CIAPIN1. CONCLUSION： The expression of RhoGDI2 is correlated with that of CIAPIN1 in gastric cancer. CIAPIN1 is very likely to be regulated by RhoGDI2, and functions as a downstream target gene of RhoGDI2 in tumor invasion and metastasis. Both of them may be involved in regulating the invasion and metastasis of gastric cancer.

关 键 词：胃癌 RhoGTP酶解离抑制蛋白2 细胞因 子诱导的凋亡抑制因子 临床病理特征 免疫组织 化学 

分 类 号：R735.2[医药卫生—肿瘤]