靛玉红自微乳制剂(SMEDDS)在大鼠体内药代动力学初步研究  

Preliminary study of indirubin SMEDDS in vivo pharmacokinetics in rats

作　　者：蒋瑶[1] 刘楠[1] 杨荣平[1] 冉继春 王云红[1] 

机构地区：[1]重庆市中药研究院,重庆400065

出　　处：《重庆中草药研究》2014年第1期13-16,共4页Chongqing Journal of Research on Chinese Drugs and Herbs

摘　　要：目的探讨SMEDDS对靛玉红口服给药生物利用度的影响。方法采用单剂量灌胃给药进行大鼠体内药代动力学试验,利用HPLC检测大鼠全血中的靛玉红含量,用DAS2.0药动学软件以统计矩方法计算药动学参数。结果靛玉红SMEDDS及原料药的AUC0→48分别为202.969和114.4μg·h·L-1,AUC0→∞分别为211.295和134.109μg·h·L-1,Cmax分别为22.35和5.4μg·L-1,Tmax分别为2h和15h,靛玉红SMEDDS相对生物利用度为靛玉红原料药灌胃液的1.58倍。结论靛玉红SMEDDS能显著提高靛玉红的口服相对生物利用度。AIM To explore the emulsion preparation for the influence of indirubin oral bioavail- ability. METHOD With a single dose lavage for rats in vivo pharmacokinetic experiment was carried out. Using HPLC to detect the contents of indirubin in whole blood of rats , with DAS 2. 0 pharmacokinetic software calculating pharmacokinetic parameters by statistical moment method. RESULT The AUC0→48 of indirubin SMEDDS and pharmaceutical raw materials liquid were 202. 969 and 114. 4μg·L^-1 ;the AUC0→∞ were 211. 295 and 134. 109μg·L^-1;the Cmax were 22. 35 and 5. 4μg·L^-1;the Tmax were 2 and 15 h. The relative bioavailability of Indirubin SMEDDS is pharmaceutical raw materials liquid for garage 1.58 times. CONCLUSION The indimbin SMEDDS significantly improve the bioavailability of indirubin.

关 键 词：SMEDDS 靛玉红 药动学 

分 类 号：R973.2[医药卫生—药品]