CD44＋／CD24-联合E-cadherin、Vimentin在非小细胞肺癌组织中的表达及临床意义  

The expression and clinical significance among CD44 ＋/CD24-, E -cadherin and vimentin in non -small cell lung cancer

作　　者：关雪睛[1] 叶磊光[1] 高越[1] 邱勋[1] 王岚[1] 王迪[1] 刘宝刚[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,哈尔滨150081

出　　处：《实用肿瘤学杂志》2014年第4期315-320,共6页Practical Oncology Journal

基　　金：黑龙江省教育厅面上项目（12531222）

摘　　要：目的检测CD44＋／CD24-与E-cadherin、Vimentin在非小细胞肺癌组织中的表达及与临床预后的关系。方法采用免疫组化法检测500例非小细胞肺癌组织CD44＋／CD24-及E-cadherin、Vi-mentin表达相关性，并分析与非小细胞肺癌的临床病理特征和预后的关系。结果非小细胞肺癌组织，Vimentin表达与组织分化程度、TNM分期相关（P〈0．05）；CD44＋／CD24-表达与淋巴结转移、肿瘤分化程度相关（P〈0．05）；CD44＋／CD24-与上皮间质转化（EMT）具有相关性（P〈0．05）；三者表达与年龄、性别、吸烟、临床病理类型无明显相关性；患者生存时间CD44＋／CD24-高表达短于低表达者（P〈0．05）；结论恶性肿瘤EMT现象“募集”了肿瘤干细胞，可导致恶性肿瘤细胞向分化差趋势发生发展；CIM4＋／CD24-与EMT在非小细胞肺癌发生、发展中起着重要作用并与患者预后相关，为突破恶性肿瘤治疗提供了潜在防治靶点。Objective To detect the expression of C1M4＋/CD24- and E - cadherin and vimentin in non -small cell lung cancer and its clinical prognostic relevance. Methods By immunohistochemistry, detecting, 500 cases of non - small cell lung cancer E - cadherin, Vimentin and CIM4 ＋/CD24 - expressions＇ correlation, we analyzed the relationship with non - small cell lung cancer. Results In non - small cell lung cancer, vimentin was related to tissue differentiation,TNM staging（P 〈 0.05） ;there was relationship between CIM4 ＋/CD24- and EMT by E - cadherin expression（ P 〈 0.05 ） ; CD44 ＋/CD24 - expression was related to lymph node metastasis, differentiation （ P 〈 0.05 ） ; their expressions were not obviously related to age, sex, smoking history, clinical patho- logical type. The survival time of CD44 ＋/CD24 - high expression in NSCLC was significantly shorter than lower expression in NSCLC （P 〈 0.05）. Conclusion EMT malignant phenomenon raises cancer stem cells, which can lead to the development of malignant ceils poorly differentiated trends, they are not an isolated process;important role in the development of EMT and CD44 ＋/CD24- union occurs in non- small cell lung cancer and prognosis with patients, which provides a potential breakthrough in the treatment of cancer prevention and treatment targets.

关 键 词：CD44+ CD24- 上皮间质转化 E-CADHERIN VIMENTIN 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]